| 1 | Sat 7 Aug 2021 | 141-1 v Cambridge UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Wed 11 Aug 2021 | 141-1 v Burton AlbionBurton Albion 1-1 Oxford United | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 142-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 14 1-2 v Bolton WanderersBolton Wanderers 2-1 Oxford United | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 143-1 v Lincoln CityOxford United 3-1 Lincoln City | Sky Bet League One |
| 6 | Sat 4 Sep 2021 | 141-3 v AFC WimbledonAFC Wimbledon 3-1 Oxford United | Sky Bet League One |
| 7 | Sat 11 Sep 2021 | 140-0 v Wycombe WanderersOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 8 | Tue 28 Sep 2021 | 145-1 v Accrington StanleyOxford United 5-1 Accrington Stanley | Sky Bet League One |
| 9 | Sat 2 Oct 2021 | 142-1 v Sheffield WednesdaySheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 10 | Tue 5 Oct 2021 | 141-2 v StevenageOxford United 1-2 Stevenage | Papa John’s Trophy |
| 11 | Sun 7 Nov 2021 | 142-2 v Bristol RoversOxford United 2-2 Bristol Rovers | Emirates FA Cup First Round |
| 12 | Tue 16 Nov 2021 | 143-4 v Bristol RoversBristol Rovers 4-3 Oxford United | Emirates FA Cup First Round Replay |
| 13 | Sat 4 Dec 2021 | 141-1 v SunderlandSunderland 1-1 Oxford United | Sky Bet League One |
| 14 | Sat 18 Dec 2021 | 142-3 v Wigan AthleticOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 15 | Wed 29 Dec 2021 | 143-0 v AFC WimbledonOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 16 | Sat 29 Jan 2022 | 147-2 v GillinghamGillingham 2-7 Oxford United | Sky Bet League One |
| 17 | Tue 8 Feb 2022 | 140-2 v Accrington StanleyAccrington Stanley 2-0 Oxford United | Sky Bet League One |
| 18 | Tue 1 Mar 2022 | 142-3 v PortsmouthPortsmouth 3-2 Oxford United | Sky Bet League One |
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