| 1 | Sat 7 Aug 2021 | 131-1 v Cambridge UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 132-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 131-0 v Crewe AlexandraOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 131-2 v Bolton WanderersBolton Wanderers 2-1 Oxford United | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 133-1 v Lincoln CityOxford United 3-1 Lincoln City | Sky Bet League One |
| 6 | Sat 4 Sep 2021 | 131-3 v AFC WimbledonAFC Wimbledon 3-1 Oxford United | Sky Bet League One |
| 7 | Sat 11 Sep 2021 | 13 0-0 v Wycombe WanderersOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 8 | Sat 18 Sep 2021 | 130-1 v Cheltenham TownCheltenham Town 1-0 Oxford United | Sky Bet League One |
| 9 | Sat 25 Sep 2021 | 131-1 v GillinghamOxford United 1-1 Gillingham | Sky Bet League One |
| 10 | Tue 28 Sep 2021 | 135-1 v Accrington StanleyOxford United 5-1 Accrington Stanley | Sky Bet League One |
| 11 | Sat 2 Oct 2021 | 132-1 v Sheffield WednesdaySheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 12 | Sat 16 Oct 2021 | 131-3 v Plymouth ArgyleOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 13 | Tue 19 Oct 2021 | 132-0 v Shrewsbury TownOxford United 2-0 Shrewsbury Town | Sky Bet League One |
| 14 | Sat 22 Jan 2022 | 133-2 v Sheffield WednesdayOxford United 3-2 Sheffield Wednesday | Sky Bet League One |
| 15 | Sat 29 Jan 2022 | 137-2 v GillinghamGillingham 2-7 Oxford United | Sky Bet League One |
| 16 | Tue 1 Feb 2022 | 131-1 v Wigan AthleticWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 17 | Sat 5 Feb 2022 | 133-2 v PortsmouthOxford United 3-2 Portsmouth | Sky Bet League One |
| 18 | Tue 8 Feb 2022 | 130-2 v Accrington StanleyAccrington Stanley 2-0 Oxford United | Sky Bet League One |
| 19 | Sat 12 Feb 2022 | 132-3 v Bolton WanderersOxford United 2-3 Bolton Wanderers | Sky Bet League One |
| 20 | Sat 19 Feb 2022 | 134-0 v Charlton AthleticCharlton Athletic 0-4 Oxford United | Sky Bet League One |
| 21 | Tue 22 Feb 2022 | 131-0 v Crewe AlexandraCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 22 | Sat 26 Feb 2022 | 134-2 v Cambridge UnitedOxford United 4-2 Cambridge United | Sky Bet League One |
| 23 | Tue 1 Mar 2022 | 132-3 v PortsmouthPortsmouth 3-2 Oxford United | Sky Bet League One |
| 24 | Sat 5 Mar 2022 | 134-1 v Burton AlbionOxford United 4-1 Burton Albion | Sky Bet League One |
| 25 | Tue 5 Apr 2022 | 131-2 v MorecambeMorecambe 2-1 Oxford United | Sky Bet League One |
| 26 | Sat 9 Apr 2022 | 131-2 v SunderlandOxford United 1-2 Sunderland | Sky Bet League One |
| 27 | Fri 15 Apr 2022 | 13 3-2 v Fleetwood TownFleetwood Town 2-3 Oxford United | Sky Bet League One |
| 28 | Tue 19 Apr 2022 | 131-0 v Milton Keynes DonsOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 29 | Sat 23 Apr 2022 | 131-2 v Rotherham UnitedRotherham United 2-1 Oxford United | Sky Bet League One |
| 30 | Sat 30 Apr 2022 | 131-1 v Doncaster RoversOxford United 1-1 Doncaster Rovers | Sky Bet League One |
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