| 1 | Sat 7 Aug 2021 | 200-2 v Rotherham UnitedRotherham United 2-0 Plymouth Argyle | Sky Bet League One |
| 2 | Tue 10 Aug 2021 | 204-0 v Peterborough UnitedPeterborough United 0-4 Plymouth Argyle | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 201-0 v GillinghamPlymouth Argyle 1-0 Gillingham | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 201-1 v Cambridge UnitedPlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 203-0 v Shrewsbury TownShrewsbury Town 0-3 Plymouth Argyle | Sky Bet League One |
| 6 | Tue 24 Aug 2021 | 201-4 v Swansea CitySwansea City 4-1 Plymouth Argyle | Carabao Cup Second Round |
| 7 | Tue 31 Aug 2021 | 20 0-2 v Newport CountyNewport County 2-0 Plymouth Argyle | Papa John’s Trophy |
| 8 | Sat 9 Oct 2021 | 202-1 v Burton AlbionPlymouth Argyle 2-1 Burton Albion | Sky Bet League One |
| 9 | Tue 12 Oct 2021 | 201-3 v Swindon TownPlymouth Argyle 1-3 Swindon Town | Papa John’s Trophy |
| 10 | Sat 30 Oct 2021 | 202-1 v Ipswich TownPlymouth Argyle 2-1 Ipswich Town | Sky Bet League One |
| 11 | Sat 13 Nov 2021 | 204-1 v Accrington StanleyAccrington Stanley 1-4 Plymouth Argyle | Sky Bet League One |
| 12 | Tue 16 Nov 2021 | 203-0 v Sheffield WednesdayPlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 13 | Sat 11 Dec 2021 | 201-2 v SunderlandSunderland 2-1 Plymouth Argyle | Sky Bet League One |
| 14 | Sat 8 Jan 2022 | 201-0 v Birmingham CityBirmingham City 0-1 Plymouth Argyle | Emirates FA Cup Third Round |
| 15 | Sat 15 Jan 2022 | 202-4 v Sheffield WednesdaySheffield Wednesday 4-2 Plymouth Argyle | Sky Bet League One |
| 16 | Sat 22 Jan 2022 | 201-2 v Lincoln CityPlymouth Argyle 1-2 Lincoln City | Sky Bet League One |
| 17 | Tue 25 Jan 2022 | 203-3 v Fleetwood TownFleetwood Town 3-3 Plymouth Argyle | Sky Bet League One |
| 18 | Sat 29 Jan 2022 | 203-1 v Doncaster RoversDoncaster Rovers 1-3 Plymouth Argyle | Sky Bet League One |
| 19 | Sat 5 Feb 2022 | 201-2 v ChelseaChelsea 2-1 Plymouth Argyle | Emirates FA Cup Fourth Round |
| 20 | Tue 8 Feb 2022 | 204-1 v Crewe AlexandraCrewe Alexandra 1-4 Plymouth Argyle | Sky Bet League One |
| 21 | Sat 12 Feb 2022 | 201-0 v Shrewsbury TownPlymouth Argyle 1-0 Shrewsbury Town | Sky Bet League One |
| 22 | Tue 22 Feb 2022 | 20 0-2 v Cambridge UnitedCambridge United 2-0 Plymouth Argyle | Sky Bet League One |
| 23 | Sat 5 Mar 2022 | 202-0 v MorecambePlymouth Argyle 2-0 Morecambe | Sky Bet League One |
| 24 | Tue 15 Mar 2022 | 201-0 v PortsmouthPlymouth Argyle 1-0 Portsmouth | Sky Bet League One |
| 25 | Sat 19 Mar 2022 | 204-0 v Accrington StanleyPlymouth Argyle 4-0 Accrington Stanley | Sky Bet League One |
| 26 | Tue 22 Mar 2022 | 202-0 v Cheltenham TownPlymouth Argyle 2-0 Cheltenham Town | Sky Bet League One |
| 27 | Sat 26 Mar 2022 | 200-1 v Ipswich TownIpswich Town 1-0 Plymouth Argyle | Sky Bet League One |
| 28 | Sat 2 Apr 2022 | 201-0 v Oxford UnitedPlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 29 | Fri 15 Apr 2022 | 200-2 v Wycombe WanderersWycombe Wanderers 2-0 Plymouth Argyle | Sky Bet League One |
| 30 | Mon 18 Apr 2022 | 200-0 v SunderlandPlymouth Argyle 0-0 Sunderland | Sky Bet League One |
| 31 | Sat 30 Apr 2022 | 200-5 v Milton Keynes DonsPlymouth Argyle 0-5 Milton Keynes Dons | Sky Bet League One |
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