| 1 | Sun 1 Aug 2021 | 6 0-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | Sat 7 Aug 2021 | 6 0-0 v Charlton AthleticCharlton Athletic 0-0 Sheffield Wednesday | Sky Bet League One |
| 3 | Sat 14 Aug 2021 | 62-0 v Doncaster RoversSheffield Wednesday 2-0 Doncaster Rovers | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 6 1-0 v Fleetwood TownSheffield Wednesday 1-0 Fleetwood Town | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 62-0 v Rotherham UnitedRotherham United 0-2 Sheffield Wednesday | Sky Bet League One |
| 6 | Sat 28 Aug 2021 | 60-1 v MorecambeMorecambe 1-0 Sheffield Wednesday | Sky Bet League One |
| 7 | Sat 11 Sep 2021 | 60-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 8 | Sat 18 Sep 2021 | 61-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 9 | Sat 25 Sep 2021 | 61-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 10 | Tue 28 Sep 2021 | 62-1 v Wigan AthleticWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 11 | Sat 2 Oct 2021 | 61-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 12 | Sat 9 Oct 2021 | 6 1-0 v Bolton WanderersSheffield Wednesday 1-0 Bolton Wanderers | Sky Bet League One |
| 13 | Sat 16 Oct 2021 | 62-2 v AFC WimbledonAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 14 | Tue 19 Oct 2021 | 61-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 15 | Sat 23 Oct 2021 | 61-1 v Lincoln CitySheffield Wednesday 1-1 Lincoln City | Sky Bet League One |
| 16 | Tue 1 Mar 2022 | 65-2 v Burton AlbionSheffield Wednesday 5-2 Burton Albion | Sky Bet League One |
| 17 | Sat 12 Mar 2022 | 66-0 v Cambridge UnitedSheffield Wednesday 6-0 Cambridge United | Sky Bet League One |
| 18 | Tue 15 Mar 2022 | 61-1 v Accrington StanleySheffield Wednesday 1-1 Accrington Stanley | Sky Bet League One |
| 19 | Sat 26 Mar 2022 | 64-1 v Cheltenham TownSheffield Wednesday 4-1 Cheltenham Town | Sky Bet League One |
| 20 | Sat 2 Apr 2022 | 62-1 v AFC WimbledonSheffield Wednesday 2-1 AFC Wimbledon | Sky Bet League One |
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