| 1 | Sat 7 Aug 2021 | 12-1 v Doncaster RoversDoncaster Rovers 1-2 AFC Wimbledon | Sky Bet League One |
| 2 | Tue 10 Aug 2021 | 11-0 v Charlton AthleticCharlton Athletic 0-1 AFC Wimbledon | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 1 3-3 v Bolton WanderersAFC Wimbledon 3-3 Bolton Wanderers | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 11-1 v GillinghamAFC Wimbledon 1-1 Gillingham | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 10-1 v SunderlandSunderland 1-0 AFC Wimbledon | Sky Bet League One |
| 6 | Tue 24 Aug 2021 | 11-0 v Northampton TownNorthampton Town 0-1 AFC Wimbledon | Carabao Cup Second Round |
| 7 | Sat 28 Aug 2021 | 12-2 v Ipswich TownIpswich Town 2-2 AFC Wimbledon | Sky Bet League One |
| 8 | Sat 4 Sep 2021 | 13-1 v Oxford UnitedAFC Wimbledon 3-1 Oxford United | Sky Bet League One |
| 9 | Sat 11 Sep 2021 | 14-3 v MorecambeMorecambe 3-4 AFC Wimbledon | Sky Bet League One |
| 10 | Sat 18 Sep 2021 | 10-1 v Plymouth ArgyleAFC Wimbledon 0-1 Plymouth Argyle | Sky Bet League One |
| 11 | Wed 22 Sep 2021 | 10-3 v ArsenalArsenal 3-0 AFC Wimbledon | Carabao Cup Third Round |
| 12 | Sat 25 Sep 2021 | 11-2 v Shrewsbury TownShrewsbury Town 2-1 AFC Wimbledon | Sky Bet League One |
| 13 | Tue 28 Sep 2021 | 10-3 v Rotherham UnitedRotherham United 3-0 AFC Wimbledon | Sky Bet League One |
| 14 | Sat 2 Oct 2021 | 11-1 v Burton AlbionAFC Wimbledon 1-1 Burton Albion | Sky Bet League One |
| 15 | Sat 16 Oct 2021 | 12-2 v Sheffield WednesdayAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 16 | Tue 19 Oct 2021 | 11-0 v Lincoln CityLincoln City 0-1 AFC Wimbledon | Sky Bet League One |
| 17 | Sat 23 Oct 2021 | 10-2 v Wigan AthleticAFC Wimbledon 0-2 Wigan Athletic | Sky Bet League One |
| 18 | Sat 30 Oct 2021 | 10-1 v Cambridge UnitedCambridge United 1-0 AFC Wimbledon | Sky Bet League One |
| 19 | Sat 6 Nov 2021 | 11-0 v GuiseleyAFC Wimbledon 1-0 Guiseley | Emirates FA Cup First Round |
| 20 | Sat 20 Nov 2021 | 11-2 v PortsmouthPortsmouth 2-1 AFC Wimbledon | Sky Bet League One |
| 21 | Tue 23 Nov 2021 | 13-2 v Crewe AlexandraAFC Wimbledon 3-2 Crewe Alexandra | Sky Bet League One |
| 22 | Sat 27 Nov 2021 | 12-2 v Fleetwood TownAFC Wimbledon 2-2 Fleetwood Town | Sky Bet League One |
| 23 | Sat 4 Dec 2021 | 14-3 v Cheltenham TownAFC Wimbledon 4-3 Cheltenham Town | Emirates FA Cup Second Round |
| 24 | Tue 7 Dec 2021 | 12-0 v Accrington StanleyAccrington Stanley 0-2 AFC Wimbledon | Sky Bet League One |
| 25 | Sat 11 Dec 2021 | 12-2 v Wycombe WanderersWycombe Wanderers 2-2 AFC Wimbledon | Sky Bet League One |
| 26 | Wed 29 Dec 2021 | 10-3 v Oxford UnitedOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 27 | Sat 8 Jan 2022 | 10-2 v Boreham WoodBoreham Wood 2-0 AFC Wimbledon | Emirates FA Cup Third Round |
| 28 | Tue 11 Jan 2022 | 10-1 v Milton Keynes DonsMilton Keynes Dons 1-0 AFC Wimbledon | Sky Bet League One |
| 29 | Sat 15 Jan 2022 | 10-0 v MorecambeAFC Wimbledon 0-0 Morecambe | Sky Bet League One |
| 30 | Tue 18 Jan 2022 | 10-0 v PortsmouthAFC Wimbledon 0-0 Portsmouth | Sky Bet League One |
| 31 | Sat 22 Jan 2022 | 11-1 v Burton AlbionBurton Albion 1-1 AFC Wimbledon | Sky Bet League One |
| 32 | Tue 25 Jan 2022 | 10-2 v Ipswich TownAFC Wimbledon 0-2 Ipswich Town | Sky Bet League One |
| 33 | Sat 29 Jan 2022 | 11-1 v Shrewsbury TownAFC Wimbledon 1-1 Shrewsbury Town | Sky Bet League One |
| 34 | Tue 1 Feb 2022 | 12-2 v Cheltenham TownAFC Wimbledon 2-2 Cheltenham Town | Sky Bet League One |
| 35 | Sat 5 Feb 2022 | 12-3 v Charlton AthleticCharlton Athletic 3-2 AFC Wimbledon | Sky Bet League One |
| 36 | Tue 8 Feb 2022 | 10-1 v Rotherham UnitedAFC Wimbledon 0-1 Rotherham United | Sky Bet League One |
| 37 | Sat 12 Feb 2022 | 11-1 v SunderlandAFC Wimbledon 1-1 Sunderland | Sky Bet League One |
| 38 | Sat 19 Feb 2022 | 10-4 v Bolton WanderersBolton Wanderers 4-0 AFC Wimbledon | Sky Bet League One |
| 39 | Tue 22 Feb 2022 | 10-0 v GillinghamGillingham 0-0 AFC Wimbledon | Sky Bet League One |
| 40 | Sat 26 Feb 2022 | 12-2 v Doncaster RoversAFC Wimbledon 2-2 Doncaster Rovers | Sky Bet League One |
| 41 | Sat 5 Mar 2022 | 10-1 v Wigan AthleticWigan Athletic 1-0 AFC Wimbledon | Sky Bet League One |
| 42 | Tue 8 Mar 2022 | 10-2 v Plymouth ArgylePlymouth Argyle 2-0 AFC Wimbledon | Sky Bet League One |
| 43 | Sat 12 Mar 2022 | 10-2 v Lincoln CityAFC Wimbledon 0-2 Lincoln City | Sky Bet League One |
| 44 | Sat 19 Mar 2022 | 11-3 v Cheltenham TownCheltenham Town 3-1 AFC Wimbledon | Sky Bet League One |
| 45 | Sat 26 Mar 2022 | 10-1 v Cambridge UnitedAFC Wimbledon 0-1 Cambridge United | Sky Bet League One |
| 46 | Sat 2 Apr 2022 | 11-2 v Sheffield WednesdaySheffield Wednesday 2-1 AFC Wimbledon | Sky Bet League One |
| 47 | Tue 5 Apr 2022 | 11-1 v Charlton AthleticAFC Wimbledon 1-1 Charlton Athletic | Sky Bet League One |
| 48 | Sat 9 Apr 2022 | 11-1 v Milton Keynes DonsAFC Wimbledon 1-1 Milton Keynes Dons | Sky Bet League One |
| 49 | Fri 15 Apr 2022 | 11-3 v Crewe AlexandraCrewe Alexandra 3-1 AFC Wimbledon | Sky Bet League One |
| 50 | Mon 18 Apr 2022 | 11-1 v Wycombe WanderersAFC Wimbledon 1-1 Wycombe Wanderers | Sky Bet League One |
| 51 | Sat 23 Apr 2022 | 11-1 v Fleetwood TownFleetwood Town 1-1 AFC Wimbledon | Sky Bet League One |
| 52 | Sat 30 Apr 2022 | 13-4 v Accrington StanleyAFC Wimbledon 3-4 Accrington Stanley | Sky Bet League One |
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