| 1 | Sun 1 Aug 2021 | 260-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | Sat 7 Aug 2021 | 260-0 v Charlton AthleticCharlton Athletic 0-0 Sheffield Wednesday | Sky Bet League One |
| 3 | Sat 14 Aug 2021 | 262-0 v Doncaster RoversSheffield Wednesday 2-0 Doncaster Rovers | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 261-0 v Fleetwood TownSheffield Wednesday 1-0 Fleetwood Town | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 26 2-0 v Rotherham UnitedRotherham United 0-2 Sheffield Wednesday | Sky Bet League One |
| 6 | Sat 28 Aug 2021 | 260-1 v MorecambeMorecambe 1-0 Sheffield Wednesday | Sky Bet League One |
| 7 | Sat 11 Sep 2021 | 260-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 8 | Sat 18 Sep 2021 | 261-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 9 | Sat 25 Sep 2021 | 261-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 10 | Tue 28 Sep 2021 | 262-1 v Wigan AthleticWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 11 | Sat 2 Oct 2021 | 261-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 12 | Tue 5 Oct 2021 | 262-1 v Mansfield TownMansfield Town 1-2 Sheffield Wednesday | Papa John’s Trophy |
| 13 | Sat 16 Oct 2021 | 262-2 v AFC WimbledonAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 14 | Tue 19 Oct 2021 | 261-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 15 | Tue 2 Nov 2021 | 263-0 v SunderlandSheffield Wednesday 3-0 Sunderland | Sky Bet League One |
| 16 | Sun 7 Nov 2021 | 26 0-0 v Plymouth ArgyleSheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 17 | Sat 13 Nov 2021 | 261-1 v GillinghamSheffield Wednesday 1-1 Gillingham | Sky Bet League One |
| 18 | Tue 16 Nov 2021 | 260-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 19 | Tue 7 Dec 2021 | 260-0 v PortsmouthPortsmouth 0-0 Sheffield Wednesday | Sky Bet League One |
| 20 | Sat 11 Dec 2021 | 262-0 v Crewe AlexandraCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 21 | Thu 30 Dec 2021 | 260-5 v SunderlandSunderland 5-0 Sheffield Wednesday | Sky Bet League One |
| 22 | Sun 2 Jan 2022 | 260-1 v Shrewsbury TownShrewsbury Town 1-0 Sheffield Wednesday | Sky Bet League One |
| 23 | Tue 8 Feb 2022 | 110-0 v Shrewsbury TownWycombe Wanderers 0-0 Shrewsbury Town | Sky Bet League One |
| 24 | Sat 12 Feb 2022 | 111-1 v Lincoln CityLincoln City 1-1 Wycombe Wanderers | Sky Bet League One |
| 25 | Sat 19 Feb 2022 | 115-5 v Cheltenham TownWycombe Wanderers 5-5 Cheltenham Town | Sky Bet League One |
| 26 | Tue 22 Feb 2022 | 111-3 v Wigan AthleticWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 27 | Tue 1 Mar 2022 | 113-0 v Cambridge UnitedWycombe Wanderers 3-0 Cambridge United | Sky Bet League One |
| 28 | Sat 5 Mar 2022 | 11 3-1 v Crewe AlexandraCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 29 | Sat 12 Mar 2022 | 110-0 v Rotherham UnitedWycombe Wanderers 0-0 Rotherham United | Sky Bet League One |
| 30 | Tue 15 Mar 2022 | 11 1-0 v Fleetwood TownWycombe Wanderers 1-0 Fleetwood Town | Sky Bet League One |
| 31 | Sat 19 Mar 2022 | 110-0 v PortsmouthPortsmouth 0-0 Wycombe Wanderers | Sky Bet League One |
| 32 | Sat 2 Apr 2022 | 112-0 v Doncaster RoversWycombe Wanderers 2-0 Doncaster Rovers | Sky Bet League One |
| 33 | Tue 5 Apr 2022 | 114-1 v Cambridge UnitedCambridge United 1-4 Wycombe Wanderers | Sky Bet League One |
| 34 | Sat 9 Apr 2022 | 11 1-1 v GillinghamGillingham 1-1 Wycombe Wanderers | Sky Bet League One |
| 35 | Sat 30 Apr 2022 | 112-1 v Burton AlbionBurton Albion 1-2 Wycombe Wanderers | Sky Bet League One |
| 36 | Sat 21 May 2022 | 110-2 v SunderlandSunderland 2-0 Wycombe Wanderers | Sky Bet League One Play-off Final |
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