| 1 | Tue 10 Aug 2021 | 80-0 v Exeter CityExeter City 0-0 Wycombe Wanderers | Carabao Cup First Round |
| 2 | Sat 14 Aug 2021 | 83-1 v Cheltenham TownCheltenham Town 1-3 Wycombe Wanderers | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 81-1 v Wigan AthleticWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 8 1-0 v Lincoln CityWycombe Wanderers 1-0 Lincoln City | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 81-3 v SunderlandSunderland 3-1 Wycombe Wanderers | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 8 0-0 v Oxford UnitedOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 82-1 v Charlton AthleticWycombe Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 80-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 82-1 v Shrewsbury TownShrewsbury Town 1-2 Wycombe Wanderers | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 84-3 v MorecambeWycombe Wanderers 4-3 Morecambe | Sky Bet League One |
| 11 | Tue 5 Oct 2021 | 8 1-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Wycombe Wanderers | Papa John’s Trophy |
| 12 | Sat 9 Oct 2021 | 82-0 v GillinghamWycombe Wanderers 2-0 Gillingham | Sky Bet League One |
| 13 | Sat 16 Oct 2021 | 82-0 v Doncaster RoversDoncaster Rovers 0-2 Wycombe Wanderers | Sky Bet League One |
| 14 | Tue 19 Oct 2021 | 80-0 v Rotherham UnitedRotherham United 0-0 Wycombe Wanderers | Sky Bet League One |
| 15 | Sat 23 Oct 2021 | 82-1 v Crewe AlexandraWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 16 | Sat 30 Oct 2021 | 83-3 v Fleetwood TownFleetwood Town 3-3 Wycombe Wanderers | Sky Bet League One |
| 17 | Sat 6 Nov 2021 | 82-2 v Hartlepool UnitedHartlepool United 2-2 Wycombe Wanderers | Emirates FA Cup First Round |
| 18 | Sat 13 Nov 2021 | 80-1 v PortsmouthWycombe Wanderers 0-1 Portsmouth | Sky Bet League One |
| 19 | Tue 16 Nov 2021 | 80-1 v Hartlepool UnitedWycombe Wanderers 0-1 Hartlepool United | Emirates FA Cup First Round Replay |
| 20 | Sat 20 Nov 2021 | 81-0 v Bolton WanderersWycombe Wanderers 1-0 Bolton Wanderers | Sky Bet League One |
| 21 | Tue 23 Nov 2021 | 83-0 v Plymouth ArgylePlymouth Argyle 0-3 Wycombe Wanderers | Sky Bet League One |
| 22 | Sat 27 Nov 2021 | 82-2 v Sheffield WednesdaySheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 23 | Tue 7 Dec 2021 | 82-1 v Burton AlbionWycombe Wanderers 2-1 Burton Albion | Sky Bet League One |
| 24 | Sat 11 Dec 2021 | 8 2-2 v AFC WimbledonWycombe Wanderers 2-2 AFC Wimbledon | Sky Bet League One |
| 25 | Wed 29 Dec 2021 | 80-1 v Ipswich TownIpswich Town 1-0 Wycombe Wanderers | Sky Bet League One |
| 26 | Tue 11 Jan 2022 | 82-0 v Bolton WanderersBolton Wanderers 0-2 Wycombe Wanderers | Sky Bet League One |
| 27 | Sat 15 Jan 2022 | 82-0 v Oxford UnitedWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 28 | Sat 22 Jan 2022 | 82-3 v MorecambeMorecambe 3-2 Wycombe Wanderers | Sky Bet League One |
| 29 | Sat 29 Jan 2022 | 80-1 v Milton Keynes DonsWycombe Wanderers 0-1 Milton Keynes Dons | Sky Bet League One |
| 30 | Tue 8 Feb 2022 | 80-0 v Shrewsbury TownWycombe Wanderers 0-0 Shrewsbury Town | Sky Bet League One |
| 31 | Sat 12 Feb 2022 | 81-1 v Lincoln CityLincoln City 1-1 Wycombe Wanderers | Sky Bet League One |
| 32 | Sat 19 Feb 2022 | 85-5 v Cheltenham TownWycombe Wanderers 5-5 Cheltenham Town | Sky Bet League One |
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