| 1 | Fri 27 Aug 2021 | 71-1 v Cheltenham TownBurton Albion 1-1 Cheltenham Town | Sky Bet League One |
| 2 | Tue 31 Aug 2021 | 71-2 v Milton Keynes DonsBurton Albion 1-2 Milton Keynes Dons | Papa John’s Trophy |
| 3 | Mon 6 Sep 2021 | 70-0 v Bolton WanderersBolton Wanderers 0-0 Burton Albion | Sky Bet League One |
| 4 | Sat 11 Sep 2021 | 71-1 v GillinghamBurton Albion 1-1 Gillingham | Sky Bet League One |
| 5 | Sat 18 Sep 2021 | 70-2 v Crewe AlexandraCrewe Alexandra 2-0 Burton Albion | Sky Bet League One |
| 6 | Sat 25 Sep 2021 | 71-2 v Lincoln CityBurton Albion 1-2 Lincoln City | Sky Bet League One |
| 7 | Sat 2 Oct 2021 | 71-1 v AFC WimbledonAFC Wimbledon 1-1 Burton Albion | Sky Bet League One |
| 8 | Tue 9 Nov 2021 | 75-0 v Wycombe WanderersWycombe Wanderers 0-5 Burton Albion | Papa John’s Trophy |
| 9 | Tue 23 Nov 2021 | 74-0 v Accrington StanleyBurton Albion 4-0 Accrington Stanley | Sky Bet League One |
| 10 | Sat 5 Feb 2022 | 280-2 v Crystal PalaceCrystal Palace 2-0 Hartlepool United | Emirates FA Cup Fourth Round |
| 11 | Tue 8 Feb 2022 | 283-1 v BarrowHartlepool United 3-1 Barrow | Sky Bet League Two |
| 12 | Sat 12 Feb 2022 | 281-0 v Crawley TownCrawley Town 0-1 Hartlepool United | Sky Bet League Two |
| 13 | Tue 15 Feb 2022 | 281-0 v Tranmere RoversHartlepool United 1-0 Tranmere Rovers | Sky Bet League Two |
| 14 | Sat 19 Feb 2022 | 281-1 v Sutton UnitedHartlepool United 1-1 Sutton United | Sky Bet League Two |
| 15 | Sat 26 Mar 2022 | 280-2 v Northampton TownNorthampton Town 2-0 Hartlepool United | Sky Bet League Two |
| 16 | Tue 29 Mar 2022 | 282-2 v Mansfield TownHartlepool United 2-2 Mansfield Town | Sky Bet League Two |
| 17 | Sat 9 Apr 2022 | 28 1-1 v Forest Green RoversForest Green Rovers 1-1 Hartlepool United | Sky Bet League Two |
| 18 | Fri 15 Apr 2022 | 280-1 v Port ValeHartlepool United 0-1 Port Vale | Sky Bet League Two |
| 19 | Mon 18 Apr 2022 | 281-2 v RochdaleRochdale 2-1 Hartlepool United | Sky Bet League Two |
| 20 | Sat 30 Apr 2022 | 28 1-1 v Scunthorpe UnitedScunthorpe United 1-1 Hartlepool United | Sky Bet League Two |
Football Web Pages