| 1 | Sat 7 Aug 2021 | 12-1 v Bristol RoversMansfield Town 2-1 Bristol Rovers | Sky Bet League Two |
| 2 | Sat 14 Aug 2021 | 12-1 v Newport CountyMansfield Town 2-1 Newport County | Sky Bet League Two |
| 3 | Tue 17 Aug 2021 | 11-1 v Colchester UnitedColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 12-3 v Bradford CityMansfield Town 2-3 Bradford City | Sky Bet League Two |
| 5 | Sat 28 Aug 2021 | 10-1 v Swindon TownSwindon Town 1-0 Mansfield Town | Sky Bet League Two |
| 6 | Sat 4 Sep 2021 | 11-3 v Harrogate TownMansfield Town 1-3 Harrogate Town | Sky Bet League Two |
| 7 | Sat 11 Sep 2021 | 11-3 v WalsallWalsall 3-1 Mansfield Town | Sky Bet League Two |
| 8 | Sat 18 Sep 2021 | 11-1 v RochdaleMansfield Town 1-1 Rochdale | Sky Bet League Two |
| 9 | Sat 25 Sep 2021 | 10-0 v Leyton OrientLeyton Orient 0-0 Mansfield Town | Sky Bet League Two |
| 10 | Sat 2 Oct 2021 | 10-1 v BarrowMansfield Town 0-1 Barrow | Sky Bet League Two |
| 11 | Sat 9 Oct 2021 | 10-0 v Oldham AthleticMansfield Town 0-0 Oldham Athletic | Sky Bet League Two |
| 12 | Sat 16 Oct 2021 | 10-2 v Northampton TownNorthampton Town 2-0 Mansfield Town | Sky Bet League Two |
| 13 | Tue 19 Oct 2021 | 11-1 v Port ValeMansfield Town 1-1 Port Vale | Sky Bet League Two |
| 14 | Sat 23 Oct 2021 | 11-2 v Exeter CityExeter City 2-1 Mansfield Town | Sky Bet League Two |
| 15 | Sat 30 Oct 2021 | 12-0 v Tranmere RoversMansfield Town 2-0 Tranmere Rovers | Sky Bet League Two |
| 16 | Sat 6 Nov 2021 | 11-0 v SunderlandSunderland 0-1 Mansfield Town | Emirates FA Cup First Round |
| 17 | Sat 13 Nov 2021 | 12-1 v StevenageStevenage 1-2 Mansfield Town | Sky Bet League Two |
| 18 | Sat 20 Nov 2021 | 13-1 v Scunthorpe UnitedMansfield Town 3-1 Scunthorpe United | Sky Bet League Two |
| 19 | Tue 23 Nov 2021 | 10-2 v Sutton UnitedSutton United 2-0 Mansfield Town | Sky Bet League Two |
| 20 | Sat 27 Nov 2021 | 12-1 v Crawley TownCrawley Town 1-2 Mansfield Town | Sky Bet League Two |
| 21 | Sat 4 Dec 2021 | 13-2 v Doncaster RoversDoncaster Rovers 2-3 Mansfield Town | Emirates FA Cup Second Round |
| 22 | Tue 7 Dec 2021 | 11-0 v Carlisle UnitedMansfield Town 1-0 Carlisle United | Sky Bet League Two |
| 23 | Sat 11 Dec 2021 | 12-1 v Salford CityMansfield Town 2-1 Salford City | Sky Bet League Two |
| 24 | Sun 26 Dec 2021 | 13-2 v Hartlepool UnitedMansfield Town 3-2 Hartlepool United | Sky Bet League Two |
| 25 | Sat 8 Jan 2022 | 12-3 v MiddlesbroughMansfield Town 2-3 Middlesbrough | Emirates FA Cup Third Round |
| 26 | Tue 11 Jan 2022 | 13-2 v Swindon TownMansfield Town 3-2 Swindon Town | Sky Bet League Two |
| 27 | Sat 15 Jan 2022 | 12-0 v WalsallMansfield Town 2-0 Walsall | Sky Bet League Two |
| 28 | Sat 22 Jan 2022 | 13-1 v BarrowBarrow 1-3 Mansfield Town | Sky Bet League Two |
| 29 | Sat 29 Jan 2022 | 12-0 v Leyton OrientMansfield Town 2-0 Leyton Orient | Sky Bet League Two |
| 30 | Tue 1 Feb 2022 | 10-0 v Harrogate TownHarrogate Town 0-0 Mansfield Town | Sky Bet League Two |
| 31 | Tue 8 Feb 2022 | 12-1 v Colchester UnitedMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 32 | Sat 12 Feb 2022 | 10-0 v Bristol RoversBristol Rovers 0-0 Mansfield Town | Sky Bet League Two |
| 33 | Sat 19 Feb 2022 | 11-1 v Newport CountyNewport County 1-1 Mansfield Town | Sky Bet League Two |
| 34 | Sat 26 Feb 2022 | 12-0 v Bradford CityBradford City 0-2 Mansfield Town | Sky Bet League Two |
| 35 | Fri 4 Mar 2022 | 12-1 v Exeter CityMansfield Town 2-1 Exeter City | Sky Bet League Two |
| 36 | Fri 11 Mar 2022 | 12-3 v Tranmere RoversTranmere Rovers 3-2 Mansfield Town | Sky Bet League Two |
| 37 | Tue 15 Mar 2022 | 11-3 v Port ValePort Vale 3-1 Mansfield Town | Sky Bet League Two |
| 38 | Tue 22 Mar 2022 | 11-0 v RochdaleRochdale 0-1 Mansfield Town | Sky Bet League Two |
| 39 | Sat 26 Mar 2022 | 12-1 v Oldham AthleticOldham Athletic 1-2 Mansfield Town | Sky Bet League Two |
| 40 | Tue 29 Mar 2022 | 12-2 v Hartlepool UnitedHartlepool United 2-2 Mansfield Town | Sky Bet League Two |
| 41 | Sat 2 Apr 2022 | 11-0 v Northampton TownMansfield Town 1-0 Northampton Town | Sky Bet League Two |
| 42 | Tue 5 Apr 2022 | 10-1 v Forest Green RoversForest Green Rovers 1-0 Mansfield Town | Sky Bet League Two |
| 43 | Sat 9 Apr 2022 | 14-0 v Scunthorpe UnitedScunthorpe United 0-4 Mansfield Town | Sky Bet League Two |
| 44 | Fri 15 Apr 2022 | 12-3 v Sutton UnitedMansfield Town 2-3 Sutton United | Sky Bet League Two |
| 45 | Mon 18 Apr 2022 | 10-1 v Carlisle UnitedCarlisle United 1-0 Mansfield Town | Sky Bet League Two |
| 46 | Sat 23 Apr 2022 | 12-0 v Crawley TownMansfield Town 2-0 Crawley Town | Sky Bet League Two |
| 47 | Tue 26 Apr 2022 | 12-0 v StevenageMansfield Town 2-0 Stevenage | Sky Bet League Two |
| 48 | Mon 2 May 2022 | 12-2 v Salford CitySalford City 2-2 Mansfield Town | Sky Bet League Two |
| 49 | Sat 7 May 2022 | 12-2 v Forest Green RoversMansfield Town 2-2 Forest Green Rovers | Sky Bet League Two |
| 50 | Sat 14 May 2022 | 12-1 v Northampton TownMansfield Town 2-1 Northampton Town | Sky Bet League Two Play-off Semi Final |
| 51 | Wed 18 May 2022 | 11-0 v Northampton TownNorthampton Town 0-1 Mansfield Town | Sky Bet League Two Play-off Semi Final |
| 52 | Sat 28 May 2022 | 10-3 v Port ValeMansfield Town 0-3 Port Vale | Sky Bet League Two Play-off Final |
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