| 1 | Tue 9 Nov 2021 | 61-0 v Charlton AthleticLeyton Orient 1-0 Charlton Athletic | Papa John’s Trophy |
| 2 | Sat 4 Dec 2021 | 64-0 v Tranmere RoversLeyton Orient 4-0 Tranmere Rovers | Emirates FA Cup Second Round |
| 3 | Sat 11 Dec 2021 | 61-2 v Crawley TownLeyton Orient 1-2 Crawley Town | Sky Bet League Two |
| 4 | Sat 18 Dec 2021 | 6 0-1 v Tranmere RoversTranmere Rovers 1-0 Leyton Orient | Sky Bet League Two |
| 5 | Tue 8 Feb 2022 | 6 0-1 v Exeter CityExeter City 1-0 Leyton Orient | Sky Bet League Two |
| 6 | Sat 12 Feb 2022 | 60-2 v Salford CityLeyton Orient 0-2 Salford City | Sky Bet League Two |
| 7 | Tue 1 Mar 2022 | 62-2 v Colchester UnitedColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 8 | Sat 5 Mar 2022 | 62-2 v StevenageLeyton Orient 2-2 Stevenage | Sky Bet League Two |
| 9 | Sat 12 Mar 2022 | 60-0 v Hartlepool UnitedHartlepool United 0-0 Leyton Orient | Sky Bet League Two |
| 10 | Tue 15 Mar 2022 | 61-1 v Forest Green RoversForest Green Rovers 1-1 Leyton Orient | Sky Bet League Two |
| 11 | Sat 19 Mar 2022 | 63-1 v RochdaleLeyton Orient 3-1 Rochdale | Sky Bet League Two |
| 12 | Tue 22 Mar 2022 | 63-0 v Harrogate TownHarrogate Town 0-3 Leyton Orient | Sky Bet League Two |
| 13 | Sat 26 Mar 2022 | 62-0 v BarrowLeyton Orient 2-0 Barrow | Sky Bet League Two |
| 14 | Sat 2 Apr 2022 | 62-0 v WalsallWalsall 0-2 Leyton Orient | Sky Bet League Two |
| 15 | Fri 15 Apr 2022 | 6 3-0 v Scunthorpe UnitedLeyton Orient 3-0 Scunthorpe United | Sky Bet League Two |
| 16 | Mon 18 Apr 2022 | 62-1 v Swindon TownSwindon Town 1-2 Leyton Orient | Sky Bet League Two |
| 17 | Sat 7 May 2022 | 60-1 v Tranmere RoversLeyton Orient 0-1 Tranmere Rovers | Sky Bet League Two |
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