| 1 | Sat 7 Aug 2021 | 82-1 v Bristol RoversMansfield Town 2-1 Bristol Rovers | Sky Bet League Two |
| 2 | Sat 14 Aug 2021 | 82-1 v Newport CountyMansfield Town 2-1 Newport County | Sky Bet League Two |
| 3 | Tue 17 Aug 2021 | 81-1 v Colchester UnitedColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 82-3 v Bradford CityMansfield Town 2-3 Bradford City | Sky Bet League Two |
| 5 | Sat 28 Aug 2021 | 8 0-1 v Swindon TownSwindon Town 1-0 Mansfield Town | Sky Bet League Two |
| 6 | Sat 4 Sep 2021 | 8 1-3 v Harrogate TownMansfield Town 1-3 Harrogate Town | Sky Bet League Two |
| 7 | Sat 18 Sep 2021 | 8 1-1 v RochdaleMansfield Town 1-1 Rochdale | Sky Bet League Two |
| 8 | Sat 25 Sep 2021 | 80-0 v Leyton OrientLeyton Orient 0-0 Mansfield Town | Sky Bet League Two |
| 9 | Sat 2 Oct 2021 | 80-1 v BarrowMansfield Town 0-1 Barrow | Sky Bet League Two |
| 10 | Sat 9 Oct 2021 | 8 0-0 v Oldham AthleticMansfield Town 0-0 Oldham Athletic | Sky Bet League Two |
| 11 | Sat 16 Oct 2021 | 80-2 v Northampton TownNorthampton Town 2-0 Mansfield Town | Sky Bet League Two |
| 12 | Tue 19 Oct 2021 | 81-1 v Port ValeMansfield Town 1-1 Port Vale | Sky Bet League Two |
| 13 | Sat 23 Oct 2021 | 81-2 v Exeter CityExeter City 2-1 Mansfield Town | Sky Bet League Two |
| 14 | Sat 30 Oct 2021 | 82-0 v Tranmere RoversMansfield Town 2-0 Tranmere Rovers | Sky Bet League Two |
| 15 | Sat 6 Nov 2021 | 81-0 v SunderlandSunderland 0-1 Mansfield Town | Emirates FA Cup First Round |
| 16 | Sat 13 Nov 2021 | 82-1 v StevenageStevenage 1-2 Mansfield Town | Sky Bet League Two |
| 17 | Sat 20 Nov 2021 | 83-1 v Scunthorpe UnitedMansfield Town 3-1 Scunthorpe United | Sky Bet League Two |
| 18 | Tue 23 Nov 2021 | 8 0-2 v Sutton UnitedSutton United 2-0 Mansfield Town | Sky Bet League Two |
| 19 | Sat 27 Nov 2021 | 82-1 v Crawley TownCrawley Town 1-2 Mansfield Town | Sky Bet League Two |
| 20 | Sat 4 Dec 2021 | 83-2 v Doncaster RoversDoncaster Rovers 2-3 Mansfield Town | Emirates FA Cup Second Round |
| 21 | Sat 8 Jan 2022 | 82-3 v MiddlesbroughMansfield Town 2-3 Middlesbrough | Emirates FA Cup Third Round |
| 22 | Tue 11 Jan 2022 | 83-2 v Swindon TownMansfield Town 3-2 Swindon Town | Sky Bet League Two |
| 23 | Sat 15 Jan 2022 | 82-0 v WalsallMansfield Town 2-0 Walsall | Sky Bet League Two |
| 24 | Sat 29 Jan 2022 | 82-0 v Leyton OrientMansfield Town 2-0 Leyton Orient | Sky Bet League Two |
| 25 | Tue 1 Feb 2022 | 8 0-0 v Harrogate TownHarrogate Town 0-0 Mansfield Town | Sky Bet League Two |
| 26 | Tue 8 Feb 2022 | 82-1 v Colchester UnitedMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 27 | Sat 12 Feb 2022 | 80-0 v Bristol RoversBristol Rovers 0-0 Mansfield Town | Sky Bet League Two |
| 28 | Sat 19 Feb 2022 | 81-1 v Newport CountyNewport County 1-1 Mansfield Town | Sky Bet League Two |
| 29 | Tue 15 Mar 2022 | 81-3 v Port ValePort Vale 3-1 Mansfield Town | Sky Bet League Two |
| 30 | Wed 18 May 2022 | 81-0 v Northampton TownNorthampton Town 0-1 Mansfield Town | Sky Bet League Two Play-off Semi Final |
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