| 1 | Tue 31 Aug 2021 | 71-3 v Harrogate TownHarrogate Town 3-1 Mansfield Town | Papa John’s Trophy |
| 2 | Sat 18 Sep 2021 | 71-1 v RochdaleMansfield Town 1-1 Rochdale | Sky Bet League Two |
| 3 | Sat 25 Sep 2021 | 70-0 v Leyton OrientLeyton Orient 0-0 Mansfield Town | Sky Bet League Two |
| 4 | Sat 2 Oct 2021 | 7 0-1 v BarrowMansfield Town 0-1 Barrow | Sky Bet League Two |
| 5 | Tue 5 Oct 2021 | 7 1-2 v Sheffield WednesdayMansfield Town 1-2 Sheffield Wednesday | Papa John’s Trophy |
| 6 | Sat 9 Oct 2021 | 70-0 v Oldham AthleticMansfield Town 0-0 Oldham Athletic | Sky Bet League Two |
| 7 | Sat 16 Oct 2021 | 7 0-2 v Northampton TownNorthampton Town 2-0 Mansfield Town | Sky Bet League Two |
| 8 | Tue 19 Oct 2021 | 71-1 v Port ValeMansfield Town 1-1 Port Vale | Sky Bet League Two |
| 9 | Sat 23 Oct 2021 | 71-2 v Exeter CityExeter City 2-1 Mansfield Town | Sky Bet League Two |
| 10 | Sat 30 Oct 2021 | 72-0 v Tranmere RoversMansfield Town 2-0 Tranmere Rovers | Sky Bet League Two |
| 11 | Sat 6 Nov 2021 | 7 1-0 v SunderlandSunderland 0-1 Mansfield Town | Emirates FA Cup First Round |
| 12 | Sat 13 Nov 2021 | 72-1 v StevenageStevenage 1-2 Mansfield Town | Sky Bet League Two |
| 13 | Sat 20 Nov 2021 | 73-1 v Scunthorpe UnitedMansfield Town 3-1 Scunthorpe United | Sky Bet League Two |
| 14 | Tue 23 Nov 2021 | 70-2 v Sutton UnitedSutton United 2-0 Mansfield Town | Sky Bet League Two |
| 15 | Sat 4 Dec 2021 | 73-2 v Doncaster RoversDoncaster Rovers 2-3 Mansfield Town | Emirates FA Cup Second Round |
| 16 | Tue 7 Dec 2021 | 71-0 v Carlisle UnitedMansfield Town 1-0 Carlisle United | Sky Bet League Two |
| 17 | Sat 11 Dec 2021 | 72-1 v Salford CityMansfield Town 2-1 Salford City | Sky Bet League Two |
| 18 | Tue 11 Jan 2022 | 73-2 v Swindon TownMansfield Town 3-2 Swindon Town | Sky Bet League Two |
| 19 | Sat 15 Jan 2022 | 72-0 v WalsallMansfield Town 2-0 Walsall | Sky Bet League Two |
| 20 | Sat 22 Jan 2022 | 73-1 v BarrowBarrow 1-3 Mansfield Town | Sky Bet League Two |
| 21 | Sat 29 Jan 2022 | 201-0 v Scunthorpe UnitedPort Vale 1-0 Scunthorpe United | Sky Bet League Two |
| 22 | Tue 1 Feb 2022 | 201-1 v Forest Green RoversPort Vale 1-1 Forest Green Rovers | Sky Bet League Two |
| 23 | Tue 8 Feb 2022 | 203-1 v Carlisle UnitedCarlisle United 1-3 Port Vale | Sky Bet League Two |
| 24 | Sat 12 Feb 2022 | 200-0 v Northampton TownPort Vale 0-0 Northampton Town | Sky Bet League Two |
| 25 | Tue 22 Feb 2022 | 201-1 v RochdaleRochdale 1-1 Port Vale | Sky Bet League Two |
| 26 | Sat 26 Feb 2022 | 202-0 v StevenagePort Vale 2-0 Stevenage | Sky Bet League Two |
| 27 | Tue 1 Mar 2022 | 20 1-1 v Harrogate TownHarrogate Town 1-1 Port Vale | Sky Bet League Two |
| 28 | Sat 5 Mar 2022 | 200-1 v Colchester UnitedColchester United 1-0 Port Vale | Sky Bet League Two |
| 29 | Sat 12 Mar 2022 | 204-1 v Crawley TownPort Vale 4-1 Crawley Town | Sky Bet League Two |
| 30 | Tue 15 Mar 2022 | 203-1 v Mansfield TownPort Vale 3-1 Mansfield Town | Sky Bet League Two |
| 31 | Sat 19 Mar 2022 | 20 2-1 v Bradford CityBradford City 1-2 Port Vale | Sky Bet League Two |
| 32 | Tue 22 Mar 2022 | 200-0 v Exeter CityPort Vale 0-0 Exeter City | Sky Bet League Two |
| 33 | Sat 26 Mar 2022 | 202-0 v Sutton UnitedPort Vale 2-0 Sutton United | Sky Bet League Two |
| 34 | Sat 2 Apr 2022 | 202-1 v BarrowBarrow 1-2 Port Vale | Sky Bet League Two |
| 35 | Tue 5 Apr 2022 | 201-0 v Salford CitySalford City 0-1 Port Vale | Sky Bet League Two |
| 36 | Sat 9 Apr 2022 | 203-2 v Oldham AthleticPort Vale 3-2 Oldham Athletic | Sky Bet League Two |
| 37 | Fri 15 Apr 2022 | 201-0 v Hartlepool UnitedHartlepool United 0-1 Port Vale | Sky Bet League Two |
| 38 | Mon 18 Apr 2022 | 201-3 v Bristol RoversPort Vale 1-3 Bristol Rovers | Sky Bet League Two |
| 39 | Sat 23 Apr 2022 | 200-2 v WalsallWalsall 2-0 Port Vale | Sky Bet League Two |
| 40 | Mon 2 May 2022 | 201-2 v Newport CountyPort Vale 1-2 Newport County | Sky Bet League Two |
| 41 | Sun 15 May 2022 | 20 1-2 v Swindon TownSwindon Town 2-1 Port Vale | Sky Bet League Two Play-off Semi Final |
| 42 | Thu 19 May 2022 | 201-0 v Swindon TownPort Vale 1-0 Swindon Town | Sky Bet League Two Play-off Semi Final |
| 43 | Sat 28 May 2022 | 203-0 v Mansfield TownMansfield Town 0-3 Port Vale | Sky Bet League Two Play-off Final |
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