| 1 | Sat 4 Sep 2021 | 140-2 v Northampton TownNorthampton Town 2-0 Scunthorpe United | Sky Bet League Two |
| 2 | Sat 11 Sep 2021 | 14 0-4 v Exeter CityScunthorpe United 0-4 Exeter City | Sky Bet League Two |
| 3 | Sat 18 Sep 2021 | 142-2 v Carlisle UnitedCarlisle United 2-2 Scunthorpe United | Sky Bet League Two |
| 4 | Sat 25 Sep 2021 | 140-1 v Port ValeScunthorpe United 0-1 Port Vale | Sky Bet League Two |
| 5 | Tue 5 Oct 2021 | 14 1-4 v Rotherham UnitedRotherham United 4-1 Scunthorpe United | Papa John’s Trophy |
| 6 | Sat 9 Oct 2021 | 141-6 v Harrogate TownHarrogate Town 6-1 Scunthorpe United | Sky Bet League Two |
| 7 | Tue 19 Oct 2021 | 141-1 v BarrowBarrow 1-1 Scunthorpe United | Sky Bet League Two |
| 8 | Sat 6 Nov 2021 | 140-1 v Doncaster RoversScunthorpe United 0-1 Doncaster Rovers | Emirates FA Cup First Round |
| 9 | Tue 9 Nov 2021 | 142-3 v Doncaster RoversScunthorpe United 2-3 Doncaster Rovers | Papa John’s Trophy |
| 10 | Sat 15 Jan 2022 | 140-2 v Exeter CityExeter City 2-0 Scunthorpe United | Sky Bet League Two |
| 11 | Sat 22 Jan 2022 | 140-1 v Newport CountyScunthorpe United 0-1 Newport County | Sky Bet League Two |
| 12 | Tue 25 Jan 2022 | 14 2-3 v Bristol RoversScunthorpe United 2-3 Bristol Rovers | Sky Bet League Two |
| 13 | Sat 29 Jan 2022 | 140-1 v Port ValePort Vale 1-0 Scunthorpe United | Sky Bet League Two |
| 14 | Tue 8 Feb 2022 | 150-0 v Matlock TownMatlock Town 0-0 Grantham Town | Northern Premier League - Premier Division |
| 15 | Tue 15 Feb 2022 | 154-3 v Ashton UnitedGrantham Town 4-3 Ashton United | Northern Premier League - Premier Division |
| 16 | Sat 26 Feb 2022 | 10 2-3 v Witton AlbionGrantham Town 2-3 Witton Albion | Northern Premier League - Premier Division |
| 17 | Sat 5 Mar 2022 | 113-2 v Morpeth TownGrantham Town 3-2 Morpeth Town | Northern Premier League - Premier Division |
| 18 | Sat 12 Mar 2022 | 81-2 v Bamber BridgeBamber Bridge 2-1 Grantham Town | Northern Premier League - Premier Division |
| 19 | Sat 19 Mar 2022 | 8 0-0 v Stalybridge CelticGrantham Town 0-0 Stalybridge Celtic | Northern Premier League - Premier Division |
| 20 | Tue 22 Mar 2022 | 80-1 v Nantwich TownNantwich Town 1-0 Grantham Town | Northern Premier League - Premier Division |
| 21 | Sat 26 Mar 2022 | 80-2 v Whitby TownGrantham Town 0-2 Whitby Town | Northern Premier League - Premier Division |
| 22 | Sat 2 Apr 2022 | 141-4 v Stafford RangersStafford Rangers 4-1 Grantham Town | Northern Premier League - Premier Division |
| 23 | Sat 9 Apr 2022 | 7 0-3 v BuxtonBuxton 3-0 Grantham Town | Northern Premier League - Premier Division |
| 24 | Sat 16 Apr 2022 | 72-0 v Hyde UnitedGrantham Town 2-0 Hyde United | Northern Premier League - Premier Division |
| 25 | Mon 18 Apr 2022 | 72-2 v Gainsborough TrinityGainsborough Trinity 2-2 Grantham Town | Northern Premier League - Premier Division |
| 26 | Sat 23 Apr 2022 | 71-0 v South ShieldsGrantham Town 1-0 South Shields | Northern Premier League - Premier Division |
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