| 1 | Sat 14 Aug 2021 | 40-0 v Port ValePort Vale 0-0 Tranmere Rovers | Sky Bet League Two |
| 2 | Tue 17 Aug 2021 | 4 0-0 v Swindon TownSwindon Town 0-0 Tranmere Rovers | Sky Bet League Two |
| 3 | Sat 21 Aug 2021 | 40-1 v Newport CountyTranmere Rovers 0-1 Newport County | Sky Bet League Two |
| 4 | Sat 28 Aug 2021 | 4 0-1 v Scunthorpe UnitedScunthorpe United 1-0 Tranmere Rovers | Sky Bet League Two |
| 5 | Sat 4 Sep 2021 | 4 1-0 v Hartlepool UnitedTranmere Rovers 1-0 Hartlepool United | Sky Bet League Two |
| 6 | Sat 11 Sep 2021 | 40-1 v RochdaleRochdale 1-0 Tranmere Rovers | Sky Bet League Two |
| 7 | Sat 18 Sep 2021 | 42-0 v Salford CityTranmere Rovers 2-0 Salford City | Sky Bet League Two |
| 8 | Tue 5 Oct 2021 | 4 2-0 v Salford CitySalford City 0-2 Tranmere Rovers | Papa John’s Trophy |
| 9 | Sat 6 Nov 2021 | 4 1-0 v Crawley TownCrawley Town 0-1 Tranmere Rovers | Emirates FA Cup First Round |
| 10 | Tue 9 Nov 2021 | 43-2 v Oldham AthleticTranmere Rovers 3-2 Oldham Athletic | Papa John’s Trophy |
| 11 | Sat 13 Nov 2021 | 4 0-1 v Sutton UnitedTranmere Rovers 0-1 Sutton United | Sky Bet League Two |
| 12 | Sat 20 Nov 2021 | 4 2-2 v Bristol RoversBristol Rovers 2-2 Tranmere Rovers | Sky Bet League Two |
| 13 | Tue 23 Nov 2021 | 42-1 v Bradford CityTranmere Rovers 2-1 Bradford City | Sky Bet League Two |
| 14 | Sat 4 Dec 2021 | 4 0-4 v Leyton OrientLeyton Orient 4-0 Tranmere Rovers | Emirates FA Cup Second Round |
| 15 | Sat 29 Jan 2022 | 40-4 v Forest Green RoversTranmere Rovers 0-4 Forest Green Rovers | Sky Bet League Two |
| 16 | Tue 1 Feb 2022 | 41-0 v StevenageTranmere Rovers 1-0 Stevenage | Sky Bet League Two |
| 17 | Sat 5 Feb 2022 | 41-1 v BarrowBarrow 1-1 Tranmere Rovers | Sky Bet League Two |
| 18 | Sat 5 Mar 2022 | 42-3 v Northampton TownNorthampton Town 3-2 Tranmere Rovers | Sky Bet League Two |
| 19 | Sat 2 Apr 2022 | 42-2 v Carlisle UnitedTranmere Rovers 2-2 Carlisle United | Sky Bet League Two |
| 20 | Sat 9 Apr 2022 | 41-1 v Bristol RoversTranmere Rovers 1-1 Bristol Rovers | Sky Bet League Two |
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