| 1 | Sun 15 Aug 2021 | 70-1 v Tottenham HotspurTottenham Hotspur 1-0 Manchester City | Premier League |
| 2 | Sat 21 Aug 2021 | 75-0 v Norwich CityManchester City 5-0 Norwich City | Premier League |
| 3 | Sat 28 Aug 2021 | 75-0 v ArsenalManchester City 5-0 Arsenal | Premier League |
| 4 | Wed 8 Sep 2021 | 101-1 v PolandPoland 1-1 England | World Cup Qualification (Europe) |
| 5 | Sat 11 Sep 2021 | 71-0 v Leicester CityLeicester City 0-1 Manchester City | Premier League |
| 6 | Wed 15 Sep 2021 | 76-3 v RB LeipzigManchester City 6-3 RB Leipzig | UEFA Champions League Group A |
| 7 | Sat 18 Sep 2021 | 70-0 v SouthamptonManchester City 0-0 Southampton | Premier League |
| 8 | Tue 21 Sep 2021 | 76-1 v Wycombe WanderersManchester City 6-1 Wycombe Wanderers | Carabao Cup Third Round |
| 9 | Sat 25 Sep 2021 | 71-0 v ChelseaChelsea 0-1 Manchester City | Premier League |
| 10 | Tue 28 Sep 2021 | 70-2 v Paris St GermainParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 11 | Sun 3 Oct 2021 | 72-2 v LiverpoolLiverpool 2-2 Manchester City | Premier League |
| 12 | Tue 12 Oct 2021 | 101-1 v HungaryEngland 1-1 Hungary | World Cup Qualification (Europe) |
| 13 | Sat 16 Oct 2021 | 72-0 v BurnleyManchester City 2-0 Burnley | Premier League |
| 14 | Tue 19 Oct 2021 | 75-1 v Club BruggeClub Brugge 1-5 Manchester City | UEFA Champions League Group A |
| 15 | Wed 27 Oct 2021 | 70-0 v West Ham UnitedWest Ham United 0-0 Manchester City | Carabao Cup Round of 16 |
| 16 | Sat 30 Oct 2021 | 70-2 v Crystal PalaceManchester City 0-2 Crystal Palace | Premier League |
| 17 | Wed 3 Nov 2021 | 74-1 v Club BruggeManchester City 4-1 Club Brugge | UEFA Champions League Group A |
| 18 | Fri 12 Nov 2021 | 105-0 v AlbaniaEngland 5-0 Albania | World Cup Qualification (Europe) |
| 19 | Sun 21 Nov 2021 | 73-0 v EvertonManchester City 3-0 Everton | Premier League |
| 20 | Wed 24 Nov 2021 | 72-1 v Paris St GermainManchester City 2-1 Paris St Germain | UEFA Champions League Group A |
| 21 | Sun 28 Nov 2021 | 72-1 v West Ham UnitedManchester City 2-1 West Ham United | Premier League |
| 22 | Wed 1 Dec 2021 | 72-1 v Aston VillaAston Villa 1-2 Manchester City | Premier League |
| 23 | Sat 4 Dec 2021 | 73-1 v WatfordWatford 1-3 Manchester City | Premier League |
| 24 | Tue 7 Dec 2021 | 71-2 v RB LeipzigRB Leipzig 2-1 Manchester City | UEFA Champions League Group A |
| 25 | Sat 11 Dec 2021 | 71-0 v Wolverhampton WanderersManchester City 1-0 Wolverhampton Wanderers | Premier League |
| 26 | Sun 19 Dec 2021 | 74-0 v Newcastle UnitedNewcastle United 0-4 Manchester City | Premier League |
| 27 | Sun 26 Dec 2021 | 76-3 v Leicester CityManchester City 6-3 Leicester City | Premier League |
| 28 | Sat 1 Jan 2022 | 72-1 v ArsenalArsenal 1-2 Manchester City | Premier League |
| 29 | Sat 15 Jan 2022 | 71-0 v ChelseaManchester City 1-0 Chelsea | Premier League |
| 30 | Sat 22 Jan 2022 | 71-1 v SouthamptonSouthampton 1-1 Manchester City | Premier League |
| 31 | Sat 5 Feb 2022 | 74-1 v FulhamManchester City 4-1 Fulham | Emirates FA Cup Fourth Round |
| 32 | Wed 9 Feb 2022 | 72-0 v BrentfordManchester City 2-0 Brentford | Premier League |
| 33 | Sat 12 Feb 2022 | 7 4-0 v Norwich CityNorwich City 0-4 Manchester City | Premier League |
| 34 | Tue 15 Feb 2022 | 75-0 v Sporting LisbonSporting Lisbon 0-5 Manchester City | UEFA Champions League Round of 16 |
| 35 | Sat 19 Feb 2022 | 72-3 v Tottenham HotspurManchester City 2-3 Tottenham Hotspur | Premier League |
| 36 | Sat 26 Feb 2022 | 71-0 v EvertonEverton 0-1 Manchester City | Premier League |
| 37 | Wed 9 Mar 2022 | 70-0 v Sporting LisbonManchester City 0-0 Sporting Lisbon | UEFA Champions League Round of 16 |
| 38 | Sun 20 Mar 2022 | 74-1 v SouthamptonSouthampton 1-4 Manchester City | Emirates FA Cup Sixth Round |
| 39 | Tue 29 Mar 2022 | 73-0 v Côte d'IvoireEngland 3-0 Côte d'Ivoire | International Friendly |
| 40 | Sat 2 Apr 2022 | 72-0 v BurnleyBurnley 0-2 Manchester City | Premier League |
| 41 | Tue 5 Apr 2022 | 71-0 v Atlético MadridManchester City 1-0 Atlético Madrid | UEFA Champions League Quarter Final |
| 42 | Sun 10 Apr 2022 | 72-2 v LiverpoolManchester City 2-2 Liverpool | Premier League |
| 43 | Wed 13 Apr 2022 | 70-0 v Atlético MadridAtlético Madrid 0-0 Manchester City | UEFA Champions League Quarter Final |
| 44 | Sat 16 Apr 2022 | 72-3 v LiverpoolManchester City 2-3 Liverpool | Emirates FA Cup Semi Final |
| 45 | Sat 23 Apr 2022 | 75-1 v WatfordManchester City 5-1 Watford | Premier League |
| 46 | Tue 26 Apr 2022 | 74-3 v Real MadridManchester City 4-3 Real Madrid | UEFA Champions League Semi Final |
| 47 | Sat 30 Apr 2022 | 74-0 v Leeds UnitedLeeds United 0-4 Manchester City | Premier League |
| 48 | Wed 4 May 2022 | 7 1-3 v Real MadridReal Madrid 3-1 Manchester City | UEFA Champions League Semi Final |
| 49 | Sun 8 May 2022 | 75-0 v Newcastle UnitedManchester City 5-0 Newcastle United | Premier League |
| 50 | Wed 11 May 2022 | 75-1 v Wolverhampton WanderersWolverhampton Wanderers 1-5 Manchester City | Premier League |
| 51 | Sun 22 May 2022 | 73-2 v Aston VillaManchester City 3-2 Aston Villa | Premier League |
| 52 | Tue 7 Jun 2022 | 101-1 v GermanyGermany 1-1 England | UEFA Nations League League A Group 3 |
| 53 | Sat 11 Jun 2022 | 100-0 v ItalyEngland 0-0 Italy | UEFA Nations League League A Group 3 |
| 54 | Tue 14 Jun 2022 | 200-4 v HungaryEngland 0-4 Hungary | UEFA Nations League League A Group 3 |
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