| 1 | Sat 14 Aug 2021 | 231-3 v EvertonEverton 3-1 Southampton | Premier League |
| 2 | Wed 25 Aug 2021 | 238-0 v Newport CountyNewport County 0-8 Southampton | Carabao Cup Second Round |
| 3 | Tue 21 Sep 2021 | 232-2 v Sheffield UnitedSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 4 | Sat 2 Oct 2021 | 231-3 v ChelseaChelsea 3-1 Southampton | Premier League |
| 5 | Sat 16 Oct 2021 | 231-0 v Leeds UnitedSouthampton 1-0 Leeds United | Premier League |
| 6 | Tue 26 Oct 2021 | 231-1 v ChelseaChelsea 1-1 Southampton | Carabao Cup Round of 16 |
| 7 | Sat 27 Nov 2021 | 230-4 v LiverpoolLiverpool 4-0 Southampton | Premier League |
| 8 | Wed 1 Dec 2021 | 232-2 v Leicester CitySouthampton 2-2 Leicester City | Premier League |
| 9 | Sat 4 Dec 2021 | 23 1-1 v Brighton & Hove AlbionSouthampton 1-1 Brighton & Hove Albion | Premier League |
| 10 | Sat 11 Dec 2021 | 230-3 v ArsenalArsenal 3-0 Southampton | Premier League |
| 11 | Wed 15 Dec 2021 | 232-2 v Crystal PalaceCrystal Palace 2-2 Southampton | Premier League |
| 12 | Sat 8 Jan 2022 | 233-2 v Swansea CitySwansea City 2-3 Southampton | Emirates FA Cup Third Round |
| 13 | Tue 11 Jan 2022 | 234-1 v BrentfordSouthampton 4-1 Brentford | Premier League |
| 14 | Sat 15 Jan 2022 | 231-3 v Wolverhampton WanderersWolverhampton Wanderers 3-1 Southampton | Premier League |
| 15 | Sat 2 Apr 2022 | 231-1 v Leeds UnitedLeeds United 1-1 Southampton | Premier League |
| 16 | Sun 24 Apr 2022 | 232-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-2 Southampton | Premier League |
| 17 | Sat 30 Apr 2022 | 231-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Premier League |
| 18 | Tue 17 May 2022 | 23 1-2 v LiverpoolSouthampton 1-2 Liverpool | Premier League |
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