| 1 | Sun 29 Aug 2021 | 71-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Manchester United | Premier League |
| 2 | Sat 25 Sep 2021 | 210-1 v Aston VillaManchester United 0-1 Aston Villa | Premier League |
| 3 | Wed 29 Sep 2021 | 212-1 v VillarrealManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 4 | Sat 2 Oct 2021 | 211-1 v EvertonManchester United 1-1 Everton | Premier League |
| 5 | Fri 15 Oct 2021 | 21 1-4 v BrazilBrazil 4-1 Uruguay | World Cup Qualification (South America) |
| 6 | Wed 20 Oct 2021 | 21 3-2 v AtalantaManchester United 3-2 Atalanta | UEFA Champions League Group F |
| 7 | Sun 24 Oct 2021 | 210-5 v LiverpoolManchester United 0-5 Liverpool | Premier League |
| 8 | Sat 30 Oct 2021 | 213-0 v Tottenham HotspurTottenham Hotspur 0-3 Manchester United | Premier League |
| 9 | Tue 2 Nov 2021 | 212-2 v AtalantaAtalanta 2-2 Manchester United | UEFA Champions League Group F |
| 10 | Mon 27 Dec 2021 | 211-1 v Newcastle UnitedNewcastle United 1-1 Manchester United | Premier League |
| 11 | Thu 30 Dec 2021 | 213-1 v BurnleyManchester United 3-1 Burnley | Premier League |
| 12 | Mon 3 Jan 2022 | 210-1 v Wolverhampton WanderersManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 13 | Mon 10 Jan 2022 | 211-0 v Aston VillaManchester United 1-0 Aston Villa | Emirates FA Cup Third Round |
| 14 | Sat 15 Jan 2022 | 212-2 v Aston VillaAston Villa 2-2 Manchester United | Premier League |
| 15 | Sat 22 Jan 2022 | 211-0 v West Ham UnitedManchester United 1-0 West Ham United | Premier League |
| 16 | Tue 8 Feb 2022 | 211-1 v BurnleyBurnley 1-1 Manchester United | Premier League |
| 17 | Sat 12 Mar 2022 | 213-2 v Tottenham HotspurManchester United 3-2 Tottenham Hotspur | Premier League |
| 18 | Tue 15 Mar 2022 | 210-1 v Atlético MadridManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 19 | Mon 2 May 2022 | 213-0 v BrentfordManchester United 3-0 Brentford | Premier League |
| 20 | Sat 7 May 2022 | 210-4 v Brighton & Hove AlbionBrighton & Hove Albion 4-0 Manchester United | Premier League |
| 21 | Sun 22 May 2022 | 210-1 v Crystal PalaceCrystal Palace 1-0 Manchester United | Premier League |
| 22 | Sun 5 Jun 2022 | 210-0 v USAUSA 0-0 Uruguay | International Friendly |
| 23 | Sat 11 Jun 2022 | 215-0 v PanamaUruguay 5-0 Panama | International Friendly |
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