| 1 | Sat 14 Aug 2021 | 23 5-1 v Leeds UnitedManchester United 5-1 Leeds United | Premier League |
| 2 | Sun 22 Aug 2021 | 231-1 v SouthamptonSouthampton 1-1 Manchester United | Premier League |
| 3 | Sun 29 Aug 2021 | 231-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Manchester United | Premier League |
| 4 | Wed 8 Sep 2021 | 31-1 v PolandPoland 1-1 England | World Cup Qualification (Europe) |
| 5 | Sat 11 Sep 2021 | 234-1 v Newcastle UnitedManchester United 4-1 Newcastle United | Premier League |
| 6 | Tue 14 Sep 2021 | 231-2 v Young BoysYoung Boys 2-1 Manchester United | UEFA Champions League Group F |
| 7 | Sun 19 Sep 2021 | 232-1 v West Ham UnitedWest Ham United 1-2 Manchester United | Premier League |
| 8 | Sat 25 Sep 2021 | 23 0-1 v Aston VillaManchester United 0-1 Aston Villa | Premier League |
| 9 | Sat 2 Oct 2021 | 231-1 v EvertonManchester United 1-1 Everton | Premier League |
| 10 | Tue 12 Oct 2021 | 3 1-1 v HungaryEngland 1-1 Hungary | World Cup Qualification (Europe) |
| 11 | Sat 16 Oct 2021 | 232-4 v Leicester CityLeicester City 4-2 Manchester United | Premier League |
| 12 | Wed 20 Oct 2021 | 23 3-2 v AtalantaManchester United 3-2 Atalanta | UEFA Champions League Group F |
| 13 | Sun 24 Oct 2021 | 23 0-5 v LiverpoolManchester United 0-5 Liverpool | Premier League |
| 14 | Sat 30 Oct 2021 | 23 3-0 v Tottenham HotspurTottenham Hotspur 0-3 Manchester United | Premier League |
| 15 | Tue 2 Nov 2021 | 232-2 v AtalantaAtalanta 2-2 Manchester United | UEFA Champions League Group F |
| 16 | Sat 6 Nov 2021 | 230-2 v Manchester CityManchester United 0-2 Manchester City | Premier League |
| 17 | Sat 20 Nov 2021 | 231-4 v WatfordWatford 4-1 Manchester United | Premier League |
| 18 | Wed 8 Dec 2021 | 231-1 v Young BoysManchester United 1-1 Young Boys | UEFA Champions League Group F |
| 19 | Thu 30 Dec 2021 | 233-1 v BurnleyManchester United 3-1 Burnley | Premier League |
| 20 | Mon 3 Jan 2022 | 23 0-1 v Wolverhampton WanderersManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 21 | Mon 10 Jan 2022 | 23 1-0 v Aston VillaManchester United 1-0 Aston Villa | Emirates FA Cup Third Round |
| 22 | Fri 4 Feb 2022 | 231-1 v MiddlesbroughManchester United 1-1 Middlesbrough | Emirates FA Cup Fourth Round |
| 23 | Tue 8 Feb 2022 | 231-1 v BurnleyBurnley 1-1 Manchester United | Premier League |
| 24 | Sat 12 Feb 2022 | 231-1 v SouthamptonManchester United 1-1 Southampton | Premier League |
| 25 | Tue 15 Feb 2022 | 23 2-0 v Brighton & Hove AlbionManchester United 2-0 Brighton & Hove Albion | Premier League |
| 26 | Sun 20 Feb 2022 | 23 4-2 v Leeds UnitedLeeds United 2-4 Manchester United | Premier League |
| 27 | Wed 23 Feb 2022 | 23 1-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 28 | Sat 26 Feb 2022 | 230-0 v WatfordManchester United 0-0 Watford | Premier League |
| 29 | Tue 29 Mar 2022 | 123-0 v Côte d'IvoireEngland 3-0 Côte d'Ivoire | International Friendly |
| 30 | Sat 2 Apr 2022 | 23 1-1 v Leicester CityManchester United 1-1 Leicester City | Premier League |
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