| 1 | Wed 25 Aug 2021 | 448-0 v Newport CountyNewport County 0-8 Southampton | Carabao Cup Second Round |
| 2 | Tue 21 Sep 2021 | 442-2 v Sheffield UnitedSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 3 | Tue 26 Oct 2021 | 44 1-1 v ChelseaChelsea 1-1 Southampton | Carabao Cup Round of 16 |
| 4 | Sun 26 Dec 2021 | 443-2 v West Ham UnitedWest Ham United 2-3 Southampton | Premier League |
| 5 | Tue 28 Dec 2021 | 441-1 v Tottenham HotspurSouthampton 1-1 Tottenham Hotspur | Premier League |
| 6 | Sat 8 Jan 2022 | 443-2 v Swansea CitySwansea City 2-3 Southampton | Emirates FA Cup Third Round |
| 7 | Tue 11 Jan 2022 | 444-1 v BrentfordSouthampton 4-1 Brentford | Premier League |
| 8 | Sat 15 Jan 2022 | 441-3 v Wolverhampton WanderersWolverhampton Wanderers 3-1 Southampton | Premier League |
| 9 | Sat 22 Jan 2022 | 441-1 v Manchester CitySouthampton 1-1 Manchester City | Premier League |
| 10 | Wed 9 Feb 2022 | 44 3-2 v Tottenham HotspurTottenham Hotspur 2-3 Southampton | Premier League |
| 11 | Sat 12 Feb 2022 | 441-1 v Manchester UnitedManchester United 1-1 Southampton | Premier League |
| 12 | Sat 19 Feb 2022 | 442-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 13 | Fri 25 Feb 2022 | 442-0 v Norwich CitySouthampton 2-0 Norwich City | Premier League |
| 14 | Sat 5 Mar 2022 | 440-4 v Aston VillaAston Villa 4-0 Southampton | Premier League |
| 15 | Thu 10 Mar 2022 | 441-2 v Newcastle UnitedSouthampton 1-2 Newcastle United | Premier League |
| 16 | Sun 13 Mar 2022 | 441-2 v WatfordSouthampton 1-2 Watford | Premier League |
| 17 | Sun 20 Mar 2022 | 441-4 v Manchester CitySouthampton 1-4 Manchester City | Emirates FA Cup Sixth Round |
| 18 | Sat 2 Apr 2022 | 441-1 v Leeds UnitedLeeds United 1-1 Southampton | Premier League |
| 19 | Sat 9 Apr 2022 | 440-6 v ChelseaSouthampton 0-6 Chelsea | Premier League |
| 20 | Sat 16 Apr 2022 | 441-0 v ArsenalSouthampton 1-0 Arsenal | Premier League |
| 21 | Thu 21 Apr 2022 | 440-2 v BurnleyBurnley 2-0 Southampton | Premier League |
| 22 | Sun 24 Apr 2022 | 442-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-2 Southampton | Premier League |
| 23 | Sat 30 Apr 2022 | 441-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Premier League |
| 24 | Sat 7 May 2022 | 440-3 v BrentfordBrentford 3-0 Southampton | Premier League |
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