| 1 | Wed 25 Aug 2021 | 78-0 v Newport CountyNewport County 0-8 Southampton | Carabao Cup Second Round |
| 2 | Sun 26 Sep 2021 | 70-1 v Wolverhampton WanderersSouthampton 0-1 Wolverhampton Wanderers | Premier League |
| 3 | Tue 26 Oct 2021 | 71-1 v ChelseaChelsea 1-1 Southampton | Carabao Cup Round of 16 |
| 4 | Wed 15 Dec 2021 | 72-2 v Crystal PalaceCrystal Palace 2-2 Southampton | Premier League |
| 5 | Tue 28 Dec 2021 | 71-1 v Tottenham HotspurSouthampton 1-1 Tottenham Hotspur | Premier League |
| 6 | Sat 8 Jan 2022 | 73-2 v Swansea CitySwansea City 2-3 Southampton | Emirates FA Cup Third Round |
| 7 | Sat 5 Feb 2022 | 72-1 v Coventry CitySouthampton 2-1 Coventry City | Emirates FA Cup Fourth Round |
| 8 | Wed 9 Feb 2022 | 73-2 v Tottenham HotspurTottenham Hotspur 2-3 Southampton | Premier League |
| 9 | Sat 19 Feb 2022 | 72-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 10 | Fri 25 Feb 2022 | 72-0 v Norwich CitySouthampton 2-0 Norwich City | Premier League |
| 11 | Wed 2 Mar 2022 | 73-1 v West Ham UnitedSouthampton 3-1 West Ham United | Emirates FA Cup Fifth Round |
| 12 | Thu 10 Mar 2022 | 71-2 v Newcastle UnitedSouthampton 1-2 Newcastle United | Premier League |
| 13 | Sun 13 Mar 2022 | 71-2 v WatfordSouthampton 1-2 Watford | Premier League |
| 14 | Sun 20 Mar 2022 | 71-4 v Manchester CitySouthampton 1-4 Manchester City | Emirates FA Cup Sixth Round |
| 15 | Sat 2 Apr 2022 | 71-1 v Leeds UnitedLeeds United 1-1 Southampton | Premier League |
| 16 | Sat 16 Apr 2022 | 7 1-0 v ArsenalSouthampton 1-0 Arsenal | Premier League |
| 17 | Sun 24 Apr 2022 | 72-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-2 Southampton | Premier League |
| 18 | Sat 30 Apr 2022 | 71-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Premier League |
| 19 | Sun 22 May 2022 | 71-4 v Leicester CityLeicester City 4-1 Southampton | Premier League |
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