| 1 | Sat 14 Aug 2021 | 51-3 v EvertonEverton 3-1 Southampton | Premier League |
| 2 | Sun 22 Aug 2021 | 5 1-1 v Manchester UnitedSouthampton 1-1 Manchester United | Premier League |
| 3 | Wed 25 Aug 2021 | 58-0 v Newport CountyNewport County 0-8 Southampton | Carabao Cup Second Round |
| 4 | Sat 28 Aug 2021 | 52-2 v Newcastle UnitedNewcastle United 2-2 Southampton | Premier League |
| 5 | Sat 11 Sep 2021 | 5 0-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 6 | Sat 18 Sep 2021 | 50-0 v Manchester CityManchester City 0-0 Southampton | Premier League |
| 7 | Sat 11 Dec 2021 | 50-3 v ArsenalArsenal 3-0 Southampton | Premier League |
| 8 | Sat 8 Jan 2022 | 5 3-2 v Swansea CitySwansea City 2-3 Southampton | Emirates FA Cup Third Round |
| 9 | Sat 5 Feb 2022 | 52-1 v Coventry CitySouthampton 2-1 Coventry City | Emirates FA Cup Fourth Round |
| 10 | Sat 12 Feb 2022 | 51-1 v Manchester UnitedManchester United 1-1 Southampton | Premier League |
| 11 | Fri 25 Feb 2022 | 52-0 v Norwich CitySouthampton 2-0 Norwich City | Premier League |
| 12 | Wed 2 Mar 2022 | 53-1 v West Ham UnitedSouthampton 3-1 West Ham United | Emirates FA Cup Fifth Round |
| 13 | Sat 5 Mar 2022 | 50-4 v Aston VillaAston Villa 4-0 Southampton | Premier League |
| 14 | Sun 20 Mar 2022 | 51-4 v Manchester CitySouthampton 1-4 Manchester City | Emirates FA Cup Sixth Round |
| 15 | Tue 17 May 2022 | 5 1-2 v LiverpoolSouthampton 1-2 Liverpool | Premier League |
| 16 | Sun 22 May 2022 | 51-4 v Leicester CityLeicester City 4-1 Southampton | Premier League |
Football Web Pages