| 1 | Sat 14 Aug 2021 | 11-3 v EvertonEverton 3-1 Southampton | Premier League |
| 2 | Sun 22 Aug 2021 | 11-1 v Manchester UnitedSouthampton 1-1 Manchester United | Premier League |
| 3 | Sat 28 Aug 2021 | 12-2 v Newcastle UnitedNewcastle United 2-2 Southampton | Premier League |
| 4 | Sat 11 Sep 2021 | 10-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 5 | Sat 18 Sep 2021 | 10-0 v Manchester CityManchester City 0-0 Southampton | Premier League |
| 6 | Sun 26 Sep 2021 | 10-1 v Wolverhampton WanderersSouthampton 0-1 Wolverhampton Wanderers | Premier League |
| 7 | Sat 2 Oct 2021 | 11-3 v ChelseaChelsea 3-1 Southampton | Premier League |
| 8 | Sat 16 Oct 2021 | 1 1-0 v Leeds UnitedSouthampton 1-0 Leeds United | Premier League |
| 9 | Sat 23 Oct 2021 | 12-2 v BurnleySouthampton 2-2 Burnley | Premier League |
| 10 | Sat 30 Oct 2021 | 11-0 v WatfordWatford 0-1 Southampton | Premier League |
| 11 | Fri 5 Nov 2021 | 11-0 v Aston VillaSouthampton 1-0 Aston Villa | Premier League |
| 12 | Sat 20 Nov 2021 | 11-2 v Norwich CityNorwich City 2-1 Southampton | Premier League |
| 13 | Sat 27 Nov 2021 | 10-4 v LiverpoolLiverpool 4-0 Southampton | Premier League |
| 14 | Wed 1 Dec 2021 | 12-2 v Leicester CitySouthampton 2-2 Leicester City | Premier League |
| 15 | Sat 4 Dec 2021 | 11-1 v Brighton & Hove AlbionSouthampton 1-1 Brighton & Hove Albion | Premier League |
| 16 | Tue 17 May 2022 | 11-2 v LiverpoolSouthampton 1-2 Liverpool | Premier League |
| 17 | Sun 22 May 2022 | 11-4 v Leicester CityLeicester City 4-1 Southampton | Premier League |
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