| 1 | Fri 13 Aug 2021 | 40-2 v BrentfordBrentford 2-0 Arsenal | Premier League |
| 2 | Sat 11 Sep 2021 | 4 1-0 v Norwich CityArsenal 1-0 Norwich City | Premier League |
| 3 | Sat 18 Sep 2021 | 41-0 v BurnleyBurnley 0-1 Arsenal | Premier League |
| 4 | Sun 26 Sep 2021 | 43-1 v Tottenham HotspurArsenal 3-1 Tottenham Hotspur | Premier League |
| 5 | Sat 2 Oct 2021 | 40-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-0 Arsenal | Premier League |
| 6 | Mon 18 Oct 2021 | 42-2 v Crystal PalaceArsenal 2-2 Crystal Palace | Premier League |
| 7 | Fri 22 Oct 2021 | 43-1 v Aston VillaArsenal 3-1 Aston Villa | Premier League |
| 8 | Tue 26 Oct 2021 | 42-0 v Leeds UnitedArsenal 2-0 Leeds United | Carabao Cup Round of 16 |
| 9 | Sat 30 Oct 2021 | 42-0 v Leicester CityLeicester City 0-2 Arsenal | Premier League |
| 10 | Sun 7 Nov 2021 | 41-0 v WatfordArsenal 1-0 Watford | Premier League |
| 11 | Sat 20 Nov 2021 | 40-4 v LiverpoolLiverpool 4-0 Arsenal | Premier League |
| 12 | Sat 27 Nov 2021 | 42-0 v Newcastle UnitedArsenal 2-0 Newcastle United | Premier League |
| 13 | Thu 2 Dec 2021 | 42-3 v Manchester UnitedManchester United 3-2 Arsenal | Premier League |
| 14 | Mon 6 Dec 2021 | 41-2 v EvertonEverton 2-1 Arsenal | Premier League |
| 15 | Sat 11 Dec 2021 | 43-0 v SouthamptonArsenal 3-0 Southampton | Premier League |
| 16 | Wed 15 Dec 2021 | 42-0 v West Ham UnitedArsenal 2-0 West Ham United | Premier League |
| 17 | Sat 18 Dec 2021 | 44-1 v Leeds UnitedLeeds United 1-4 Arsenal | Premier League |
| 18 | Tue 21 Dec 2021 | 45-1 v SunderlandArsenal 5-1 Sunderland | Carabao Cup Quarter Final |
| 19 | Sun 26 Dec 2021 | 45-0 v Norwich CityNorwich City 0-5 Arsenal | Premier League |
| 20 | Sat 1 Jan 2022 | 41-2 v Manchester CityArsenal 1-2 Manchester City | Premier League |
| 21 | Sun 9 Jan 2022 | 40-1 v Nottingham ForestNottingham Forest 1-0 Arsenal | Emirates FA Cup Third Round |
| 22 | Thu 13 Jan 2022 | 40-0 v LiverpoolLiverpool 0-0 Arsenal | Carabao Cup Semi Final |
| 23 | Thu 20 Jan 2022 | 40-2 v LiverpoolArsenal 0-2 Liverpool | Carabao Cup Semi Final |
| 24 | Sun 23 Jan 2022 | 40-0 v BurnleyArsenal 0-0 Burnley | Premier League |
| 25 | Thu 10 Feb 2022 | 41-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Arsenal | Premier League |
| 26 | Sat 19 Feb 2022 | 42-1 v BrentfordArsenal 2-1 Brentford | Premier League |
| 27 | Thu 24 Feb 2022 | 42-1 v Wolverhampton WanderersArsenal 2-1 Wolverhampton Wanderers | Premier League |
| 28 | Sun 6 Mar 2022 | 43-2 v WatfordWatford 2-3 Arsenal | Premier League |
| 29 | Sun 13 Mar 2022 | 42-0 v Leicester CityArsenal 2-0 Leicester City | Premier League |
| 30 | Wed 16 Mar 2022 | 40-2 v LiverpoolArsenal 0-2 Liverpool | Premier League |
| 31 | Sat 19 Mar 2022 | 41-0 v Aston VillaAston Villa 0-1 Arsenal | Premier League |
| 32 | Tue 29 Mar 2022 | 23-0 v Côte d'IvoireEngland 3-0 Côte d'Ivoire | International Friendly |
| 33 | Mon 4 Apr 2022 | 40-3 v Crystal PalaceCrystal Palace 3-0 Arsenal | Premier League |
| 34 | Sat 9 Apr 2022 | 41-2 v Brighton & Hove AlbionArsenal 1-2 Brighton & Hove Albion | Premier League |
| 35 | Sat 16 Apr 2022 | 4 0-1 v SouthamptonSouthampton 1-0 Arsenal | Premier League |
| 36 | Wed 20 Apr 2022 | 44-2 v ChelseaChelsea 2-4 Arsenal | Premier League |
| 37 | Sat 23 Apr 2022 | 43-1 v Manchester UnitedArsenal 3-1 Manchester United | Premier League |
| 38 | Mon 16 May 2022 | 4 0-2 v Newcastle UnitedNewcastle United 2-0 Arsenal | Premier League |
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