| 1 | Sun 15 Aug 2021 | 21-0 v Manchester CityTottenham Hotspur 1-0 Manchester City | Premier League |
| 2 | Thu 19 Aug 2021 | 20-1 v Paços de FerreiraPaços de Ferreira 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 3 | Thu 26 Aug 2021 | 23-0 v Paços de FerreiraTottenham Hotspur 3-0 Paços de Ferreira | UEFA Europa Conference League |
| 4 | Tue 7 Sep 2021 | 21-1 v SerbiaRepublic of Ireland 1-1 Serbia | World Cup Qualification (Europe) |
| 5 | Thu 16 Sep 2021 | 22-2 v RennesRennes 2-2 Tottenham Hotspur | UEFA Europa Conference League |
| 6 | Thu 30 Sep 2021 | 25-1 v Mura Murska SobotaTottenham Hotspur 5-1 Mura Murska Sobota | UEFA Europa Conference League |
| 7 | Sat 9 Oct 2021 | 23-0 v AzerbaijanAzerbaijan 0-3 Republic of Ireland | World Cup Qualification (Europe) |
| 8 | Tue 12 Oct 2021 | 24-0 v QatarRepublic of Ireland 4-0 Qatar | International Friendly |
| 9 | Sun 7 Nov 2021 | 20-0 v EvertonEverton 0-0 Tottenham Hotspur | Premier League |
| 10 | Sun 14 Nov 2021 | 103-0 v LuxembourgLuxembourg 0-3 Republic of Ireland | World Cup Qualification (Europe) |
| 11 | Thu 25 Nov 2021 | 21-2 v Mura Murska SobotaMura Murska Sobota 2-1 Tottenham Hotspur | UEFA Europa Conference League |
| 12 | Sun 5 Dec 2021 | 23-0 v Norwich CityTottenham Hotspur 3-0 Norwich City | Premier League |
| 13 | Wed 22 Dec 2021 | 22-1 v West Ham UnitedTottenham Hotspur 2-1 West Ham United | Carabao Cup Quarter Final |
| 14 | Tue 28 Dec 2021 | 21-1 v SouthamptonSouthampton 1-1 Tottenham Hotspur | Premier League |
| 15 | Wed 5 Jan 2022 | 20-2 v ChelseaChelsea 2-0 Tottenham Hotspur | Carabao Cup Semi Final |
| 16 | Sun 9 Jan 2022 | 23-1 v MorecambeTottenham Hotspur 3-1 Morecambe | Emirates FA Cup Third Round |
| 17 | Wed 12 Jan 2022 | 20-1 v ChelseaTottenham Hotspur 0-1 Chelsea | Carabao Cup Semi Final |
| 18 | Wed 19 Jan 2022 | 23-2 v Leicester CityLeicester City 2-3 Tottenham Hotspur | Premier League |
| 19 | Sun 23 Jan 2022 | 20-2 v ChelseaChelsea 2-0 Tottenham Hotspur | Premier League |
| 20 | Sat 5 Feb 2022 | 23-1 v Brighton & Hove AlbionTottenham Hotspur 3-1 Brighton & Hove Albion | Emirates FA Cup Fourth Round |
| 21 | Sun 13 Feb 2022 | 20-2 v Wolverhampton WanderersTottenham Hotspur 0-2 Wolverhampton Wanderers | Premier League |
| 22 | Sat 19 Feb 2022 | 23-2 v Manchester CityManchester City 2-3 Tottenham Hotspur | Premier League |
| 23 | Sat 26 Feb 2022 | 24-0 v Leeds UnitedLeeds United 0-4 Tottenham Hotspur | Premier League |
| 24 | Tue 1 Mar 2022 | 20-1 v MiddlesbroughMiddlesbrough 1-0 Tottenham Hotspur | Emirates FA Cup Fifth Round |
| 25 | Mon 7 Mar 2022 | 25-0 v EvertonTottenham Hotspur 5-0 Everton | Premier League |
| 26 | Sat 12 Mar 2022 | 22-3 v Manchester UnitedManchester United 3-2 Tottenham Hotspur | Premier League |
| 27 | Wed 16 Mar 2022 | 22-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Tottenham Hotspur | Premier League |
| 28 | Sun 20 Mar 2022 | 23-1 v West Ham UnitedTottenham Hotspur 3-1 West Ham United | Premier League |
| 29 | Tue 29 Mar 2022 | 101-0 v LithuaniaRepublic of Ireland 1-0 Lithuania | International Friendly |
| 30 | Sun 3 Apr 2022 | 25-1 v Newcastle UnitedTottenham Hotspur 5-1 Newcastle United | Premier League |
| 31 | Sat 9 Apr 2022 | 24-0 v Aston VillaAston Villa 0-4 Tottenham Hotspur | Premier League |
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