| 1 | Tue 21 Sep 2021 | 4 2-2 v Sheffield UnitedSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 2 | Tue 26 Oct 2021 | 41-1 v ChelseaChelsea 1-1 Southampton | Carabao Cup Round of 16 |
| 3 | Sat 30 Oct 2021 | 41-0 v WatfordWatford 0-1 Southampton | Premier League |
| 4 | Fri 5 Nov 2021 | 41-0 v Aston VillaSouthampton 1-0 Aston Villa | Premier League |
| 5 | Sat 20 Nov 2021 | 41-2 v Norwich CityNorwich City 2-1 Southampton | Premier League |
| 6 | Sat 27 Nov 2021 | 40-4 v LiverpoolLiverpool 4-0 Southampton | Premier League |
| 7 | Wed 1 Dec 2021 | 42-2 v Leicester CitySouthampton 2-2 Leicester City | Premier League |
| 8 | Sat 4 Dec 2021 | 41-1 v Brighton & Hove AlbionSouthampton 1-1 Brighton & Hove Albion | Premier League |
| 9 | Sat 11 Dec 2021 | 40-3 v ArsenalArsenal 3-0 Southampton | Premier League |
| 10 | Wed 15 Dec 2021 | 4 2-2 v Crystal PalaceCrystal Palace 2-2 Southampton | Premier League |
| 11 | Tue 11 Jan 2022 | 44-1 v BrentfordSouthampton 4-1 Brentford | Premier League |
| 12 | Sat 15 Jan 2022 | 4 1-3 v Wolverhampton WanderersWolverhampton Wanderers 3-1 Southampton | Premier League |
| 13 | Sat 22 Jan 2022 | 41-1 v Manchester CitySouthampton 1-1 Manchester City | Premier League |
| 14 | Sat 5 Feb 2022 | 42-1 v Coventry CitySouthampton 2-1 Coventry City | Emirates FA Cup Fourth Round |
| 15 | Sat 16 Apr 2022 | 41-0 v ArsenalSouthampton 1-0 Arsenal | Premier League |
| 16 | Thu 21 Apr 2022 | 40-2 v BurnleyBurnley 2-0 Southampton | Premier League |
| 17 | Tue 17 May 2022 | 41-2 v LiverpoolSouthampton 1-2 Liverpool | Premier League |
| 18 | Sun 22 May 2022 | 41-4 v Leicester CityLeicester City 4-1 Southampton | Premier League |
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