| 1 | Sun 1 Aug 2021 | 42-3 v HibernianMotherwell 2-3 Hibernian | Cinch Premiership |
| 2 | Sun 8 Aug 2021 | 41-1 v St JohnstoneSt Johnstone 1-1 Motherwell | Cinch Premiership |
| 3 | Sat 21 Aug 2021 | 42-1 v LivingstonLivingston 1-2 Motherwell | Cinch Premiership |
| 4 | Sat 28 Aug 2021 | 41-0 v DundeeMotherwell 1-0 Dundee | Cinch Premiership |
| 5 | Sat 11 Sep 2021 | 42-0 v AberdeenMotherwell 2-0 Aberdeen | Cinch Premiership |
| 6 | Sun 19 Sep 2021 | 41-1 v RangersRangers 1-1 Motherwell | Cinch Premiership |
| 7 | Sat 25 Sep 2021 | 42-1 v Ross CountyMotherwell 2-1 Ross County | Cinch Premiership |
| 8 | Sun 31 Oct 2021 | 41-6 v RangersMotherwell 1-6 Rangers | Cinch Premiership |
| 9 | Sat 6 Nov 2021 | 42-0 v AberdeenAberdeen 0-2 Motherwell | Cinch Premiership |
| 10 | Sat 20 Nov 2021 | 42-0 v Heart of MidlothianMotherwell 2-0 Heart of Midlothian | Cinch Premiership |
| 11 | Sat 27 Nov 2021 | 40-3 v DundeeDundee 3-0 Motherwell | Cinch Premiership |
| 12 | Tue 30 Nov 2021 | 41-0 v Dundee UnitedMotherwell 1-0 Dundee United | Cinch Premiership |
| 13 | Sat 4 Dec 2021 | 41-1 v HibernianHibernian 1-1 Motherwell | Cinch Premiership |
| 14 | Sat 12 Feb 2022 | 42-1 v AberdeenMotherwell 2-1 Aberdeen | William Hill Scottish Cup Fifth Round |
| 15 | Sat 19 Feb 2022 | 4 1-1 v AberdeenMotherwell 1-1 Aberdeen | Cinch Premiership |
| 16 | Sun 27 Feb 2022 | 42-2 v RangersRangers 2-2 Motherwell | Cinch Premiership |
| 17 | Wed 2 Mar 2022 | 40-1 v Ross CountyMotherwell 0-1 Ross County | Cinch Premiership |
| 18 | Sat 5 Mar 2022 | 41-1 v DundeeMotherwell 1-1 Dundee | Cinch Premiership |
| 19 | Sun 13 Mar 2022 | 4 1-2 v HibernianMotherwell 1-2 Hibernian | William Hill Scottish Cup Quarter Final |
| 20 | Sat 19 Mar 2022 | 41-2 v St JohnstoneSt Johnstone 2-1 Motherwell | Cinch Premiership |
| 21 | Sat 2 Apr 2022 | 44-2 v St MirrenMotherwell 4-2 St Mirren | Cinch Premiership |
| 22 | Sat 9 Apr 2022 | 42-2 v LivingstonLivingston 2-2 Motherwell | Cinch Premiership |
| 23 | Sat 23 Apr 2022 | 41-3 v RangersMotherwell 1-3 Rangers | Cinch Premiership |
| 24 | Sat 30 Apr 2022 | 40-1 v Dundee UnitedDundee United 1-0 Motherwell | Cinch Premiership |
| 25 | Sat 7 May 2022 | 41-0 v Ross CountyRoss County 0-1 Motherwell | Cinch Premiership |
| 26 | Wed 11 May 2022 | 42-1 v Heart of MidlothianMotherwell 2-1 Heart of Midlothian | Cinch Premiership |
| 27 | Sat 14 May 2022 | 4 0-6 v CelticCeltic 6-0 Motherwell | Cinch Premiership |
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