| 1 | Sat 8 Jan 2022 | 90-1 v Taunton TownDorchester Town 0-1 Taunton Town | Southern League - Premier South |
| 2 | Sat 15 Jan 2022 | 110-2 v Beaconsfield TownBeaconsfield Town 2-0 Dorchester Town | Southern League - Premier South |
| 3 | Sat 22 Jan 2022 | 91-2 v Chesham UnitedDorchester Town 1-2 Chesham United | Southern League - Premier South |
| 4 | Tue 25 Jan 2022 | 91-1 v Truro CityDorchester Town 1-1 Truro City | Southern League - Premier South |
| 5 | Sat 29 Jan 2022 | 90-3 v Hayes & Yeading UnitedHayes & Yeading United 3-0 Dorchester Town | Southern League - Premier South |
| 6 | Sat 5 Feb 2022 | 91-1 v Tiverton TownDorchester Town 1-1 Tiverton Town | Southern League - Premier South |
| 7 | Sat 12 Feb 2022 | 90-1 v Hartley WintneyHartley Wintney 1-0 Dorchester Town | Southern League - Premier South |
| 8 | Sat 26 Feb 2022 | 102-1 v Swindon SupermarineDorchester Town 2-1 Swindon Supermarine | Southern League - Premier South |
| 9 | Sat 5 Mar 2022 | 101-3 v Merthyr TownDorchester Town 1-3 Merthyr Town | Southern League - Premier South |
| 10 | Sat 19 Mar 2022 | 112-1 v Kings LangleyKings Langley 1-2 Dorchester Town | Southern League - Premier South |
| 11 | Tue 22 Mar 2022 | 90-1 v FarnboroughFarnborough 1-0 Dorchester Town | Southern League - Premier South |
| 12 | Sat 26 Mar 2022 | 90-1 v Metropolitan PoliceDorchester Town 0-1 Metropolitan Police | Southern League - Premier South |
| 13 | Sat 2 Apr 2022 | 91-0 v Wimborne TownWimborne Town 0-1 Dorchester Town | Southern League - Premier South |
| 14 | Sat 9 Apr 2022 | 73-0 v HendonDorchester Town 3-0 Hendon | Southern League - Premier South |
| 15 | Sat 16 Apr 2022 | 71-0 v SalisburySalisbury 0-1 Dorchester Town | Southern League - Premier South |
| 16 | Sat 23 Apr 2022 | 91-1 v Walton CasualsWalton Casuals 1-1 Dorchester Town | Southern League - Premier South |
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