| 1 | Sun 15 Aug 2021 | 4 2-1 v Celta VigoCelta Vigo 1-2 Atlético Madrid | Spanish La Liga |
| 2 | Sun 22 Aug 2021 | 4 1-0 v ElcheAtlético Madrid 1-0 Elche | Spanish La Liga |
| 3 | Sun 29 Aug 2021 | 42-2 v VillarrealAtlético Madrid 2-2 Villarreal | Spanish La Liga |
| 4 | Sun 12 Sep 2021 | 4 2-1 v EspanyolEspanyol 1-2 Atlético Madrid | Spanish La Liga |
| 5 | Wed 15 Sep 2021 | 4 0-0 v FC PortoAtlético Madrid 0-0 FC Porto | UEFA Champions League Group B |
| 6 | Sat 18 Sep 2021 | 4 0-0 v Athletic BilbaoAtlético Madrid 0-0 Athletic Bilbao | Spanish La Liga |
| 7 | Sat 25 Sep 2021 | 4 0-1 v AlavésAlavés 1-0 Atlético Madrid | Spanish La Liga |
| 8 | Tue 28 Sep 2021 | 4 2-1 v AC MilanAC Milan 1-2 Atlético Madrid | UEFA Champions League Group B |
| 9 | Tue 19 Oct 2021 | 42-3 v LiverpoolAtlético Madrid 2-3 Liverpool | UEFA Champions League Group B |
| 10 | Sun 24 Oct 2021 | 42-2 v Real SociedadAtlético Madrid 2-2 Real Sociedad | Spanish La Liga |
| 11 | Sun 7 Nov 2021 | 43-3 v ValenciaValencia 3-3 Atlético Madrid | Spanish La Liga |
| 12 | Sat 20 Nov 2021 | 41-0 v OsasunaAtlético Madrid 1-0 Osasuna | Spanish La Liga |
| 13 | Wed 24 Nov 2021 | 40-1 v AC MilanAtlético Madrid 0-1 AC Milan | UEFA Champions League Group B |
| 14 | Sat 4 Dec 2021 | 41-2 v MallorcaAtlético Madrid 1-2 Mallorca | Spanish La Liga |
| 15 | Tue 7 Dec 2021 | 43-1 v FC PortoFC Porto 1-3 Atlético Madrid | UEFA Champions League Group B |
| 16 | Sun 12 Dec 2021 | 4 0-2 v Real MadridReal Madrid 2-0 Atlético Madrid | Spanish La Liga |
| 17 | Sat 18 Dec 2021 | 41-2 v SevillaSevilla 2-1 Atlético Madrid | Spanish La Liga |
| 18 | Wed 22 Dec 2021 | 41-2 v GranadaGranada 2-1 Atlético Madrid | Spanish La Liga |
| 19 | Sun 2 Jan 2022 | 42-0 v Rayo VallecanoAtlético Madrid 2-0 Rayo Vallecano | Spanish La Liga |
| 20 | Sun 9 Jan 2022 | 4 2-2 v VillarrealVillarreal 2-2 Atlético Madrid | Spanish La Liga |
| 21 | Sat 12 Feb 2022 | 44-3 v GetafeAtlético Madrid 4-3 Getafe | Spanish La Liga |
| 22 | Wed 16 Feb 2022 | 40-1 v LevanteAtlético Madrid 0-1 Levante | Spanish La Liga |
| 23 | Sat 19 Feb 2022 | 43-0 v OsasunaOsasuna 0-3 Atlético Madrid | Spanish La Liga |
| 24 | Wed 23 Feb 2022 | 41-1 v Manchester UnitedAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 25 | Sat 26 Feb 2022 | 42-0 v Celta VigoAtlético Madrid 2-0 Celta Vigo | Spanish La Liga |
| 26 | Tue 15 Mar 2022 | 41-0 v Manchester UnitedManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 27 | Sat 19 Mar 2022 | 4 1-0 v Rayo VallecanoRayo Vallecano 0-1 Atlético Madrid | Spanish La Liga |
| 28 | Sat 2 Apr 2022 | 44-1 v AlavésAtlético Madrid 4-1 Alavés | Spanish La Liga |
| 29 | Tue 5 Apr 2022 | 40-1 v Manchester CityManchester City 1-0 Atlético Madrid | UEFA Champions League Quarter Final |
| 30 | Sat 9 Apr 2022 | 4 0-1 v MallorcaMallorca 1-0 Atlético Madrid | Spanish La Liga |
| 31 | Wed 13 Apr 2022 | 40-0 v Manchester CityAtlético Madrid 0-0 Manchester City | UEFA Champions League Quarter Final |
| 32 | Sun 17 Apr 2022 | 4 2-1 v EspanyolAtlético Madrid 2-1 Espanyol | Spanish La Liga |
| 33 | Sat 30 Apr 2022 | 40-2 v Athletic BilbaoAthletic Bilbao 2-0 Atlético Madrid | Spanish La Liga |
| 34 | Sun 8 May 2022 | 41-0 v Real MadridAtlético Madrid 1-0 Real Madrid | Spanish La Liga |
| 35 | Wed 11 May 2022 | 4 2-0 v ElcheElche 0-2 Atlético Madrid | Spanish La Liga |
| 36 | Sun 15 May 2022 | 4 1-1 v SevillaAtlético Madrid 1-1 Sevilla | Spanish La Liga |
| 37 | Sun 22 May 2022 | 42-1 v Real SociedadReal Sociedad 1-2 Atlético Madrid | Spanish La Liga |
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