| 1 | Sun 15 Aug 2021 | 2 2-1 v Celta VigoCelta Vigo 1-2 Atlético Madrid | Spanish La Liga |
| 2 | Sun 22 Aug 2021 | 21-0 v ElcheAtlético Madrid 1-0 Elche | Spanish La Liga |
| 3 | Sun 29 Aug 2021 | 22-2 v VillarrealAtlético Madrid 2-2 Villarreal | Spanish La Liga |
| 4 | Wed 15 Sep 2021 | 20-0 v FC PortoAtlético Madrid 0-0 FC Porto | UEFA Champions League Group B |
| 5 | Sat 18 Sep 2021 | 2 0-0 v Athletic BilbaoAtlético Madrid 0-0 Athletic Bilbao | Spanish La Liga |
| 6 | Tue 21 Sep 2021 | 2 2-1 v GetafeGetafe 1-2 Atlético Madrid | Spanish La Liga |
| 7 | Tue 28 Sep 2021 | 22-1 v AC MilanAC Milan 1-2 Atlético Madrid | UEFA Champions League Group B |
| 8 | Sat 2 Oct 2021 | 22-0 v BarcelonaAtlético Madrid 2-0 Barcelona | Spanish La Liga |
| 9 | Tue 19 Oct 2021 | 22-3 v LiverpoolAtlético Madrid 2-3 Liverpool | UEFA Champions League Group B |
| 10 | Thu 28 Oct 2021 | 2 2-2 v LevanteLevante 2-2 Atlético Madrid | Spanish La Liga |
| 11 | Sun 31 Oct 2021 | 23-0 v Real BetisAtlético Madrid 3-0 Real Betis | Spanish La Liga |
| 12 | Wed 3 Nov 2021 | 20-2 v LiverpoolLiverpool 2-0 Atlético Madrid | UEFA Champions League Group B |
| 13 | Sun 7 Nov 2021 | 23-3 v ValenciaValencia 3-3 Atlético Madrid | Spanish La Liga |
| 14 | Tue 16 Nov 2021 | 20-3 v BoliviaBolivia 3-0 Uruguay | World Cup Qualification (South America) |
| 15 | Wed 24 Nov 2021 | 20-1 v AC MilanAtlético Madrid 0-1 AC Milan | UEFA Champions League Group B |
| 16 | Sun 28 Nov 2021 | 24-1 v CádizCádiz 1-4 Atlético Madrid | Spanish La Liga |
| 17 | Sun 2 Jan 2022 | 2 2-0 v Rayo VallecanoAtlético Madrid 2-0 Rayo Vallecano | Spanish La Liga |
| 18 | Sat 22 Jan 2022 | 2 3-2 v ValenciaAtlético Madrid 3-2 Valencia | Spanish La Liga |
| 19 | Sun 6 Feb 2022 | 22-4 v BarcelonaBarcelona 4-2 Atlético Madrid | Spanish La Liga |
| 20 | Wed 16 Feb 2022 | 20-1 v LevanteAtlético Madrid 0-1 Levante | Spanish La Liga |
| 21 | Sat 19 Feb 2022 | 23-0 v OsasunaOsasuna 0-3 Atlético Madrid | Spanish La Liga |
| 22 | Wed 23 Feb 2022 | 2 1-1 v Manchester UnitedAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 23 | Sat 26 Feb 2022 | 2 2-0 v Celta VigoAtlético Madrid 2-0 Celta Vigo | Spanish La Liga |
| 24 | Sun 6 Mar 2022 | 23-1 v Real BetisReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 25 | Fri 11 Mar 2022 | 22-1 v CádizAtlético Madrid 2-1 Cádiz | Spanish La Liga |
| 26 | Tue 15 Mar 2022 | 21-0 v Manchester UnitedManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 27 | Sat 19 Mar 2022 | 21-0 v Rayo VallecanoRayo Vallecano 0-1 Atlético Madrid | Spanish La Liga |
| 28 | Sat 2 Apr 2022 | 24-1 v AlavésAtlético Madrid 4-1 Alavés | Spanish La Liga |
| 29 | Sat 30 Apr 2022 | 20-2 v Athletic BilbaoAthletic Bilbao 2-0 Atlético Madrid | Spanish La Liga |
| 30 | Sun 8 May 2022 | 21-0 v Real MadridAtlético Madrid 1-0 Real Madrid | Spanish La Liga |
| 31 | Wed 11 May 2022 | 22-0 v ElcheElche 0-2 Atlético Madrid | Spanish La Liga |
| 32 | Sun 15 May 2022 | 21-1 v SevillaAtlético Madrid 1-1 Sevilla | Spanish La Liga |
| 33 | Sun 5 Jun 2022 | 20-0 v USAUSA 0-0 Uruguay | International Friendly |
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