| 1 | Fri 20 Aug 2021 | 161-1 v CádizReal Betis 1-1 Cádiz | Spanish La Liga |
| 2 | Fri 27 Aug 2021 | 160-1 v MallorcaMallorca 1-0 Espanyol | Spanish La Liga |
| 3 | Sun 12 Sep 2021 | 161-2 v Atlético MadridEspanyol 1-2 Atlético Madrid | Spanish La Liga |
| 4 | Sun 19 Sep 2021 | 162-2 v Real BetisReal Betis 2-2 Espanyol | Spanish La Liga |
| 5 | Sat 25 Sep 2021 | 160-2 v SevillaSevilla 2-0 Espanyol | Spanish La Liga |
| 6 | Mon 18 Oct 2021 | 162-0 v CádizEspanyol 2-0 Cádiz | Spanish La Liga |
| 7 | Sun 31 Oct 2021 | 161-2 v GetafeGetafe 2-1 Espanyol | Spanish La Liga |
| 8 | Sat 20 Nov 2021 | 160-1 v BarcelonaBarcelona 1-0 Espanyol | Spanish La Liga |
| 9 | Sun 28 Nov 2021 | 161-0 v Real SociedadEspanyol 1-0 Real Sociedad | Spanish La Liga |
| 10 | Sun 5 Dec 2021 | 160-1 v Rayo VallecanoRayo Vallecano 1-0 Espanyol | Spanish La Liga |
| 11 | Sat 11 Dec 2021 | 164-3 v LevanteEspanyol 4-3 Levante | Spanish La Liga |
| 12 | Fri 17 Dec 2021 | 161-3 v Celta VigoCelta Vigo 3-1 Espanyol | Spanish La Liga |
| 13 | Fri 31 Dec 2021 | 162-1 v ValenciaValencia 1-2 Espanyol | Spanish La Liga |
| 14 | Mon 10 Jan 2022 | 161-2 v ElcheEspanyol 1-2 Elche | Spanish La Liga |
| 15 | Tue 18 Jan 2022 | 162-2 v CádizCádiz 2-2 Espanyol | Spanish La Liga |
| 16 | Fri 21 Jan 2022 | 161-4 v Real BetisEspanyol 1-4 Real Betis | Spanish La Liga |
| 17 | Mon 7 Feb 2022 | 161-2 v Athletic BilbaoAthletic Bilbao 2-1 Espanyol | Spanish La Liga |
| 18 | Sun 20 Feb 2022 | 161-1 v SevillaEspanyol 1-1 Sevilla | Spanish La Liga |
| 19 | Sat 5 Mar 2022 | 162-0 v GetafeEspanyol 2-0 Getafe | Spanish La Liga |
| 20 | Sun 20 Mar 2022 | 161-0 v MallorcaEspanyol 1-0 Mallorca | Spanish La Liga |
| 21 | Mon 4 Apr 2022 | 160-1 v Real SociedadReal Sociedad 1-0 Espanyol | Spanish La Liga |
| 22 | Thu 21 Apr 2022 | 160-1 v Rayo VallecanoEspanyol 0-1 Rayo Vallecano | Spanish La Liga |
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