| 1 | Mon 20 Sep 2021 | 31-1 v BarcelonaBarcelona 1-1 Granada | Spanish La Liga |
| 2 | Thu 23 Sep 2021 | 32-3 v Real SociedadGranada 2-3 Real Sociedad | Spanish La Liga |
| 3 | Mon 27 Sep 2021 | 30-1 v Celta VigoCelta Vigo 1-0 Granada | Spanish La Liga |
| 4 | Sun 3 Oct 2021 | 31-0 v SevillaGranada 1-0 Sevilla | Spanish La Liga |
| 5 | Fri 22 Oct 2021 | 31-1 v OsasunaOsasuna 1-1 Granada | Spanish La Liga |
| 6 | Thu 28 Oct 2021 | 31-1 v GetafeGranada 1-1 Getafe | Spanish La Liga |
| 7 | Mon 1 Nov 2021 | 3 3-0 v LevanteLevante 0-3 Granada | Spanish La Liga |
| 8 | Sat 6 Nov 2021 | 30-2 v EspanyolEspanyol 2-0 Granada | Spanish La Liga |
| 9 | Sun 21 Nov 2021 | 31-4 v Real MadridGranada 1-4 Real Madrid | Spanish La Liga |
| 10 | Fri 26 Nov 2021 | 32-2 v Athletic BilbaoAthletic Bilbao 2-2 Granada | Spanish La Liga |
| 11 | Fri 3 Dec 2021 | 32-1 v AlavésGranada 2-1 Alavés | Spanish La Liga |
| 12 | Mon 13 Dec 2021 | 31-1 v CádizCádiz 1-1 Granada | Spanish La Liga |
| 13 | Sun 19 Dec 2021 | 34-1 v MallorcaGranada 4-1 Mallorca | Spanish La Liga |
| 14 | Wed 22 Dec 2021 | 32-1 v Atlético MadridGranada 2-1 Atlético Madrid | Spanish La Liga |
| 15 | Sat 8 Jan 2022 | 31-1 v BarcelonaGranada 1-1 Barcelona | Spanish La Liga |
| 16 | Thu 20 Jan 2022 | 32-4 v GetafeGetafe 4-2 Granada | Spanish La Liga |
| 17 | Sun 23 Jan 2022 | 30-2 v OsasunaGranada 0-2 Osasuna | Spanish La Liga |
| 18 | Sun 13 Feb 2022 | 3 0-2 v Real SociedadReal Sociedad 2-0 Granada | Spanish La Liga |
| 19 | Sat 19 Mar 2022 | 3 3-2 v AlavésAlavés 2-3 Granada | Spanish La Liga |
| 20 | Sun 3 Apr 2022 | 32-2 v Rayo VallecanoGranada 2-2 Rayo Vallecano | Spanish La Liga |
| 21 | Fri 8 Apr 2022 | 32-4 v SevillaSevilla 4-2 Granada | Spanish La Liga |
| 22 | Sun 17 Apr 2022 | 31-4 v LevanteGranada 1-4 Levante | Spanish La Liga |
| 23 | Wed 20 Apr 2022 | 3 0-0 v Atlético MadridAtlético Madrid 0-0 Granada | Spanish La Liga |
| 24 | Sun 1 May 2022 | 31-1 v Celta VigoGranada 1-1 Celta Vigo | Spanish La Liga |
| 25 | Sat 7 May 2022 | 36-2 v MallorcaMallorca 2-6 Granada | Spanish La Liga |
| 26 | Tue 10 May 2022 | 3 1-0 v Athletic BilbaoGranada 1-0 Athletic Bilbao | Spanish La Liga |
| 27 | Sun 22 May 2022 | 3 0-0 v EspanyolGranada 0-0 Espanyol | Spanish La Liga |
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