| 1 | Sun 15 Aug 2021 | 43-0 v Rayo VallecanoSevilla 3-0 Rayo Vallecano | Spanish La Liga |
| 2 | Mon 23 Aug 2021 | 41-0 v GetafeGetafe 0-1 Sevilla | Spanish La Liga |
| 3 | Sat 28 Aug 2021 | 41-1 v ElcheElche 1-1 Sevilla | Spanish La Liga |
| 4 | Sun 19 Sep 2021 | 40-0 v Real SociedadReal Sociedad 0-0 Sevilla | Spanish La Liga |
| 5 | Wed 22 Sep 2021 | 43-1 v ValenciaSevilla 3-1 Valencia | Spanish La Liga |
| 6 | Sat 25 Sep 2021 | 42-0 v EspanyolSevilla 2-0 Espanyol | Spanish La Liga |
| 7 | Wed 29 Sep 2021 | 4 1-1 v VfL WolfsburgVfL Wolfsburg 1-1 Sevilla | UEFA Champions League Group G |
| 8 | Sun 17 Oct 2021 | 41-0 v Celta VigoCelta Vigo 0-1 Sevilla | Spanish La Liga |
| 9 | Wed 20 Oct 2021 | 40-0 v LilleLille 0-0 Sevilla | UEFA Champions League Group G |
| 10 | Tue 23 Nov 2021 | 42-0 v VfL WolfsburgSevilla 2-0 VfL Wolfsburg | UEFA Champions League Group G |
| 11 | Wed 8 Dec 2021 | 40-1 v SV Red Bull SalzburgSV Red Bull Salzburg 1-0 Sevilla | UEFA Champions League Group G |
| 12 | Sat 11 Dec 2021 | 4 1-0 v Athletic BilbaoAthletic Bilbao 0-1 Sevilla | Spanish La Liga |
| 13 | Sat 18 Dec 2021 | 4 2-1 v Atlético MadridSevilla 2-1 Atlético Madrid | Spanish La Liga |
| 14 | Tue 21 Dec 2021 | 41-1 v BarcelonaSevilla 1-1 Barcelona | Spanish La Liga |
| 15 | Mon 3 Jan 2022 | 41-0 v CádizCádiz 0-1 Sevilla | Spanish La Liga |
| 16 | Wed 19 Jan 2022 | 41-1 v ValenciaValencia 1-1 Sevilla | Spanish La Liga |
| 17 | Sat 22 Jan 2022 | 42-2 v Celta VigoSevilla 2-2 Celta Vigo | Spanish La Liga |
| 18 | Sat 5 Feb 2022 | 40-0 v OsasunaOsasuna 0-0 Sevilla | Spanish La Liga |
| 19 | Fri 11 Feb 2022 | 42-0 v ElcheSevilla 2-0 Elche | Spanish La Liga |
| 20 | Thu 17 Feb 2022 | 43-1 v Dinamo ZagrebSevilla 3-1 Dinamo Zagreb | UEFA Europa League Round of 32 |
| 21 | Sun 3 Apr 2022 | 40-1 v BarcelonaBarcelona 1-0 Sevilla | Spanish La Liga |
| 22 | Sun 15 May 2022 | 41-1 v Atlético MadridAtlético Madrid 1-1 Sevilla | Spanish La Liga |
| 23 | Sun 22 May 2022 | 41-0 v Athletic BilbaoSevilla 1-0 Athletic Bilbao | Spanish La Liga |
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