| 1 | Sun 12 Sep 2021 | 7 2-1 v EspanyolEspanyol 1-2 Atlético Madrid | Spanish La Liga |
| 2 | Wed 15 Sep 2021 | 7 0-0 v FC PortoAtlético Madrid 0-0 FC Porto | UEFA Champions League Group B |
| 3 | Sat 18 Sep 2021 | 7 0-0 v Athletic BilbaoAtlético Madrid 0-0 Athletic Bilbao | Spanish La Liga |
| 4 | Tue 28 Sep 2021 | 72-1 v AC MilanAC Milan 1-2 Atlético Madrid | UEFA Champions League Group B |
| 5 | Sat 2 Oct 2021 | 72-0 v BarcelonaAtlético Madrid 2-0 Barcelona | Spanish La Liga |
| 6 | Tue 19 Oct 2021 | 72-3 v LiverpoolAtlético Madrid 2-3 Liverpool | UEFA Champions League Group B |
| 7 | Sun 24 Oct 2021 | 72-2 v Real SociedadAtlético Madrid 2-2 Real Sociedad | Spanish La Liga |
| 8 | Thu 28 Oct 2021 | 72-2 v LevanteLevante 2-2 Atlético Madrid | Spanish La Liga |
| 9 | Sun 31 Oct 2021 | 73-0 v Real BetisAtlético Madrid 3-0 Real Betis | Spanish La Liga |
| 10 | Wed 3 Nov 2021 | 7 0-2 v LiverpoolLiverpool 2-0 Atlético Madrid | UEFA Champions League Group B |
| 11 | Sun 7 Nov 2021 | 73-3 v ValenciaValencia 3-3 Atlético Madrid | Spanish La Liga |
| 12 | Sun 14 Nov 2021 | 231-2 v SerbiaPortugal 1-2 Serbia | World Cup Qualification (Europe) |
| 13 | Sat 4 Dec 2021 | 71-2 v MallorcaAtlético Madrid 1-2 Mallorca | Spanish La Liga |
| 14 | Sun 12 Dec 2021 | 70-2 v Real MadridReal Madrid 2-0 Atlético Madrid | Spanish La Liga |
| 15 | Sat 18 Dec 2021 | 71-2 v SevillaSevilla 2-1 Atlético Madrid | Spanish La Liga |
| 16 | Wed 22 Dec 2021 | 71-2 v GranadaGranada 2-1 Atlético Madrid | Spanish La Liga |
| 17 | Sun 9 Jan 2022 | 72-2 v VillarrealVillarreal 2-2 Atlético Madrid | Spanish La Liga |
| 18 | Sat 22 Jan 2022 | 73-2 v ValenciaAtlético Madrid 3-2 Valencia | Spanish La Liga |
| 19 | Sun 6 Feb 2022 | 72-4 v BarcelonaBarcelona 4-2 Atlético Madrid | Spanish La Liga |
| 20 | Sat 12 Feb 2022 | 74-3 v GetafeAtlético Madrid 4-3 Getafe | Spanish La Liga |
| 21 | Wed 16 Feb 2022 | 70-1 v LevanteAtlético Madrid 0-1 Levante | Spanish La Liga |
| 22 | Sat 19 Feb 2022 | 73-0 v OsasunaOsasuna 0-3 Atlético Madrid | Spanish La Liga |
| 23 | Wed 23 Feb 2022 | 71-1 v Manchester UnitedAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 24 | Sat 26 Feb 2022 | 72-0 v Celta VigoAtlético Madrid 2-0 Celta Vigo | Spanish La Liga |
| 25 | Sun 6 Mar 2022 | 73-1 v Real BetisReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 26 | Fri 11 Mar 2022 | 72-1 v CádizAtlético Madrid 2-1 Cádiz | Spanish La Liga |
| 27 | Tue 15 Mar 2022 | 71-0 v Manchester UnitedManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 28 | Sat 19 Mar 2022 | 71-0 v Rayo VallecanoRayo Vallecano 0-1 Atlético Madrid | Spanish La Liga |
| 29 | Thu 24 Mar 2022 | 233-1 v TurkeyPortugal 3-1 Turkey | World Cup Qualification (Europe) |
| 30 | Tue 29 Mar 2022 | 232-0 v North MacedoniaPortugal 2-0 North Macedonia | World Cup Qualification (Europe) |
| 31 | Sat 2 Apr 2022 | 74-1 v AlavésAtlético Madrid 4-1 Alavés | Spanish La Liga |
| 32 | Tue 5 Apr 2022 | 70-1 v Manchester CityManchester City 1-0 Atlético Madrid | UEFA Champions League Quarter Final |
| 33 | Sat 9 Apr 2022 | 70-1 v MallorcaMallorca 1-0 Atlético Madrid | Spanish La Liga |
| 34 | Wed 13 Apr 2022 | 70-0 v Manchester CityAtlético Madrid 0-0 Manchester City | UEFA Champions League Quarter Final |
| 35 | Sun 17 Apr 2022 | 72-1 v EspanyolAtlético Madrid 2-1 Espanyol | Spanish La Liga |
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