| 1 | Sun 15 Aug 2021 | 130-3 v SevillaSevilla 3-0 Rayo Vallecano | Spanish La Liga |
| 2 | Sun 22 Aug 2021 | 130-1 v Real SociedadReal Sociedad 1-0 Rayo Vallecano | Spanish La Liga |
| 3 | Sun 29 Aug 2021 | 134-0 v GranadaRayo Vallecano 4-0 Granada | Spanish La Liga |
| 4 | Sun 5 Sep 2021 | 12-2 v IcelandIceland 2-2 North Macedonia | World Cup Qualification (Europe) |
| 5 | Wed 8 Sep 2021 | 10-0 v RomaniaNorth Macedonia 0-0 Romania | World Cup Qualification (Europe) |
| 6 | Sat 11 Sep 2021 | 131-1 v LevanteLevante 1-1 Rayo Vallecano | Spanish La Liga |
| 7 | Sat 18 Sep 2021 | 133-0 v GetafeRayo Vallecano 3-0 Getafe | Spanish La Liga |
| 8 | Tue 21 Sep 2021 | 132-1 v Athletic BilbaoAthletic Bilbao 1-2 Rayo Vallecano | Spanish La Liga |
| 9 | Sun 26 Sep 2021 | 133-1 v CádizRayo Vallecano 3-1 Cádiz | Spanish La Liga |
| 10 | Sat 2 Oct 2021 | 130-1 v OsasunaOsasuna 1-0 Rayo Vallecano | Spanish La Liga |
| 11 | Mon 11 Oct 2021 | 10-4 v GermanyNorth Macedonia 0-4 Germany | World Cup Qualification (Europe) |
| 12 | Sun 17 Oct 2021 | 132-1 v ElcheRayo Vallecano 2-1 Elche | Spanish La Liga |
| 13 | Sun 24 Oct 2021 | 132-3 v Real BetisReal Betis 3-2 Rayo Vallecano | Spanish La Liga |
| 14 | Wed 27 Oct 2021 | 131-0 v BarcelonaRayo Vallecano 1-0 Barcelona | Spanish La Liga |
| 15 | Mon 1 Nov 2021 | 130-0 v Celta VigoRayo Vallecano 0-0 Celta Vigo | Spanish La Liga |
| 16 | Sat 6 Nov 2021 | 131-2 v Real MadridReal Madrid 2-1 Rayo Vallecano | Spanish La Liga |
| 17 | Thu 11 Nov 2021 | 15-0 v ArmeniaArmenia 0-5 North Macedonia | World Cup Qualification (Europe) |
| 18 | Sun 14 Nov 2021 | 1 3-1 v IcelandNorth Macedonia 3-1 Iceland | World Cup Qualification (Europe) |
| 19 | Mon 22 Nov 2021 | 133-1 v MallorcaRayo Vallecano 3-1 Mallorca | Spanish La Liga |
| 20 | Sat 27 Nov 2021 | 131-1 v ValenciaValencia 1-1 Rayo Vallecano | Spanish La Liga |
| 21 | Sun 5 Dec 2021 | 131-0 v EspanyolRayo Vallecano 1-0 Espanyol | Spanish La Liga |
| 22 | Sun 12 Dec 2021 | 130-2 v VillarrealVillarreal 2-0 Rayo Vallecano | Spanish La Liga |
| 23 | Sat 18 Dec 2021 | 132-0 v AlavésRayo Vallecano 2-0 Alavés | Spanish La Liga |
| 24 | Sat 5 Feb 2022 | 130-2 v Celta VigoCelta Vigo 2-0 Rayo Vallecano | Spanish La Liga |
| 25 | Sat 12 Feb 2022 | 130-3 v OsasunaRayo Vallecano 0-3 Osasuna | Spanish La Liga |
| 26 | Sun 13 Mar 2022 | 131-1 v SevillaRayo Vallecano 1-1 Sevilla | Spanish La Liga |
| 27 | Sat 19 Mar 2022 | 130-1 v Atlético MadridRayo Vallecano 0-1 Atlético Madrid | Spanish La Liga |
| 28 | Thu 24 Mar 2022 | 11-0 v ItalyItaly 0-1 North Macedonia | World Cup Qualification (Europe) |
| 29 | Tue 29 Mar 2022 | 10-2 v PortugalPortugal 2-0 North Macedonia | World Cup Qualification (Europe) |
| 30 | Sun 3 Apr 2022 | 132-2 v GranadaGranada 2-2 Rayo Vallecano | Spanish La Liga |
| 31 | Mon 11 Apr 2022 | 131-1 v ValenciaRayo Vallecano 1-1 Valencia | Spanish La Liga |
| 32 | Sat 16 Apr 2022 | 130-1 v AlavésAlavés 1-0 Rayo Vallecano | Spanish La Liga |
| 33 | Thu 21 Apr 2022 | 131-0 v EspanyolEspanyol 0-1 Rayo Vallecano | Spanish La Liga |
| 34 | Sun 24 Apr 2022 | 131-0 v BarcelonaBarcelona 0-1 Rayo Vallecano | Spanish La Liga |
| 35 | Sun 1 May 2022 | 131-1 v Real SociedadRayo Vallecano 1-1 Real Sociedad | Spanish La Liga |
| 36 | Sun 8 May 2022 | 130-0 v GetafeGetafe 0-0 Rayo Vallecano | Spanish La Liga |
| 37 | Thu 12 May 2022 | 131-5 v VillarrealRayo Vallecano 1-5 Villarreal | Spanish La Liga |
| 38 | Sun 15 May 2022 | 131-2 v MallorcaMallorca 2-1 Rayo Vallecano | Spanish La Liga |
| 39 | Thu 2 Jun 2022 | 11-1 v BulgariaBulgaria 1-1 North Macedonia | UEFA Nations League League C Group 4 |
| 40 | Thu 9 Jun 2022 | 10-3 v GeorgiaNorth Macedonia 0-3 Georgia | UEFA Nations League League C Group 4 |
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