| 1 | Sat 14 Aug 2021 | 61-1 v MallorcaMallorca 1-1 Real Betis | Spanish La Liga |
| 2 | Fri 20 Aug 2021 | 61-1 v CádizReal Betis 1-1 Cádiz | Spanish La Liga |
| 3 | Sat 28 Aug 2021 | 60-1 v Real MadridReal Betis 0-1 Real Madrid | Spanish La Liga |
| 4 | Mon 13 Sep 2021 | 62-1 v GranadaGranada 1-2 Real Betis | Spanish La Liga |
| 5 | Thu 16 Sep 2021 | 64-3 v CelticReal Betis 4-3 Celtic | UEFA Europa League Group G |
| 6 | Sun 19 Sep 2021 | 62-2 v EspanyolReal Betis 2-2 Espanyol | Spanish La Liga |
| 7 | Wed 27 Oct 2021 | 6 4-1 v ValenciaReal Betis 4-1 Valencia | Spanish La Liga |
| 8 | Thu 4 Nov 2021 | 60-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-0 Real Betis | UEFA Europa League Group G |
| 9 | Sun 21 Nov 2021 | 63-0 v ElcheElche 0-3 Real Betis | Spanish La Liga |
| 10 | Sun 28 Nov 2021 | 6 3-1 v LevanteReal Betis 3-1 Levante | Spanish La Liga |
| 11 | Sat 4 Dec 2021 | 61-0 v BarcelonaBarcelona 0-1 Real Betis | Spanish La Liga |
| 12 | Sun 12 Dec 2021 | 64-0 v Real SociedadReal Betis 4-0 Real Sociedad | Spanish La Liga |
| 13 | Sun 19 Dec 2021 | 62-3 v Athletic BilbaoAthletic Bilbao 3-2 Real Betis | Spanish La Liga |
| 14 | Sun 2 Jan 2022 | 60-2 v Celta VigoReal Betis 0-2 Celta Vigo | Spanish La Liga |
| 15 | Fri 21 Jan 2022 | 64-1 v EspanyolEspanyol 1-4 Real Betis | Spanish La Liga |
| 16 | Sun 20 Feb 2022 | 6 2-1 v MallorcaReal Betis 2-1 Mallorca | Spanish La Liga |
| 17 | Sun 27 Feb 2022 | 61-2 v SevillaSevilla 2-1 Real Betis | Spanish La Liga |
| 18 | Sun 6 Mar 2022 | 61-3 v Atlético MadridReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 19 | Sun 3 Apr 2022 | 64-1 v OsasunaReal Betis 4-1 Osasuna | Spanish La Liga |
| 20 | Mon 2 May 2022 | 60-0 v GetafeGetafe 0-0 Real Betis | Spanish La Liga |
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