| 1 | Mon 13 Sep 2021 | 52-1 v GranadaGranada 1-2 Real Betis | Spanish La Liga |
| 2 | Thu 30 Sep 2021 | 53-1 v Ferencvárosi TCFerencvárosi TC 1-3 Real Betis | UEFA Europa League Group G |
| 3 | Mon 18 Oct 2021 | 51-0 v AlavésAlavés 0-1 Real Betis | Spanish La Liga |
| 4 | Sun 24 Oct 2021 | 53-2 v Rayo VallecanoReal Betis 3-2 Rayo Vallecano | Spanish La Liga |
| 5 | Thu 4 Nov 2021 | 50-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-0 Real Betis | UEFA Europa League Group G |
| 6 | Thu 25 Nov 2021 | 52-0 v Ferencvárosi TCReal Betis 2-0 Ferencvárosi TC | UEFA Europa League Group G |
| 7 | Sun 28 Nov 2021 | 53-1 v LevanteReal Betis 3-1 Levante | Spanish La Liga |
| 8 | Sat 4 Dec 2021 | 51-0 v BarcelonaBarcelona 0-1 Real Betis | Spanish La Liga |
| 9 | Sun 12 Dec 2021 | 54-0 v Real SociedadReal Betis 4-0 Real Sociedad | Spanish La Liga |
| 10 | Sun 19 Dec 2021 | 52-3 v Athletic BilbaoAthletic Bilbao 3-2 Real Betis | Spanish La Liga |
| 11 | Sun 2 Jan 2022 | 50-2 v Celta VigoReal Betis 0-2 Celta Vigo | Spanish La Liga |
| 12 | Sun 9 Jan 2022 | 51-1 v Rayo VallecanoRayo Vallecano 1-1 Real Betis | Spanish La Liga |
| 13 | Sun 6 Feb 2022 | 50-2 v VillarrealReal Betis 0-2 Villarreal | Spanish La Liga |
| 14 | Sun 13 Feb 2022 | 54-2 v LevanteLevante 2-4 Real Betis | Spanish La Liga |
| 15 | Sun 20 Feb 2022 | 52-1 v MallorcaReal Betis 2-1 Mallorca | Spanish La Liga |
| 16 | Sun 27 Feb 2022 | 51-2 v SevillaSevilla 2-1 Real Betis | Spanish La Liga |
| 17 | Sun 6 Mar 2022 | 5 1-3 v Atlético MadridReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 18 | Sun 13 Mar 2022 | 51-0 v Athletic BilbaoReal Betis 1-0 Athletic Bilbao | Spanish La Liga |
| 19 | Thu 17 Mar 2022 | 51-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Real Betis | UEFA Europa League Round of 16 |
| 20 | Sun 20 Mar 2022 | 50-0 v Celta VigoCelta Vigo 0-0 Real Betis | Spanish La Liga |
| 21 | Sun 3 Apr 2022 | 54-1 v OsasunaReal Betis 4-1 Osasuna | Spanish La Liga |
| 22 | Sat 9 Apr 2022 | 5 2-1 v CádizCádiz 1-2 Real Betis | Spanish La Liga |
| 23 | Fri 15 Apr 2022 | 5 0-0 v Real SociedadReal Sociedad 0-0 Real Betis | Spanish La Liga |
| 24 | Tue 19 Apr 2022 | 50-1 v ElcheReal Betis 0-1 Elche | Spanish La Liga |
| 25 | Sat 7 May 2022 | 5 1-2 v BarcelonaReal Betis 1-2 Barcelona | Spanish La Liga |
| 26 | Tue 10 May 2022 | 5 3-0 v ValenciaValencia 0-3 Real Betis | Spanish La Liga |
| 27 | Fri 20 May 2022 | 50-0 v Real MadridReal Madrid 0-0 Real Betis | Spanish La Liga |
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