| 1 | Tue 14 Sep 2021 | 51-1 v SV Red Bull SalzburgSevilla 1-1 SV Red Bull Salzburg | UEFA Champions League Group G |
| 2 | Sun 19 Sep 2021 | 50-0 v Real SociedadReal Sociedad 0-0 Sevilla | Spanish La Liga |
| 3 | Wed 22 Sep 2021 | 53-1 v ValenciaSevilla 3-1 Valencia | Spanish La Liga |
| 4 | Sat 25 Sep 2021 | 52-0 v EspanyolSevilla 2-0 Espanyol | Spanish La Liga |
| 5 | Wed 29 Sep 2021 | 51-1 v VfL WolfsburgVfL Wolfsburg 1-1 Sevilla | UEFA Champions League Group G |
| 6 | Sun 3 Oct 2021 | 5 0-1 v GranadaGranada 1-0 Sevilla | Spanish La Liga |
| 7 | Sun 17 Oct 2021 | 51-0 v Celta VigoCelta Vigo 0-1 Sevilla | Spanish La Liga |
| 8 | Wed 20 Oct 2021 | 50-0 v LilleLille 0-0 Sevilla | UEFA Champions League Group G |
| 9 | Sun 24 Oct 2021 | 55-3 v LevanteSevilla 5-3 Levante | Spanish La Liga |
| 10 | Wed 27 Oct 2021 | 51-1 v MallorcaMallorca 1-1 Sevilla | Spanish La Liga |
| 11 | Sat 30 Oct 2021 | 52-0 v OsasunaSevilla 2-0 Osasuna | Spanish La Liga |
| 12 | Tue 2 Nov 2021 | 5 1-2 v LilleSevilla 1-2 Lille | UEFA Champions League Group G |
| 13 | Sun 7 Nov 2021 | 52-0 v Real BetisReal Betis 0-2 Sevilla | Spanish La Liga |
| 14 | Sat 20 Nov 2021 | 5 2-2 v AlavésSevilla 2-2 Alavés | Spanish La Liga |
| 15 | Tue 23 Nov 2021 | 52-0 v VfL WolfsburgSevilla 2-0 VfL Wolfsburg | UEFA Champions League Group G |
| 16 | Sun 28 Nov 2021 | 5 1-2 v Real MadridReal Madrid 2-1 Sevilla | Spanish La Liga |
| 17 | Sat 4 Dec 2021 | 51-0 v VillarrealSevilla 1-0 Villarreal | Spanish La Liga |
| 18 | Wed 8 Dec 2021 | 5 0-1 v SV Red Bull SalzburgSV Red Bull Salzburg 1-0 Sevilla | UEFA Champions League Group G |
| 19 | Sat 18 Dec 2021 | 52-1 v Atlético MadridSevilla 2-1 Atlético Madrid | Spanish La Liga |
| 20 | Tue 21 Dec 2021 | 51-1 v BarcelonaSevilla 1-1 Barcelona | Spanish La Liga |
| 21 | Mon 3 Jan 2022 | 51-0 v CádizCádiz 0-1 Sevilla | Spanish La Liga |
| 22 | Sun 9 Jan 2022 | 5 1-0 v GetafeSevilla 1-0 Getafe | Spanish La Liga |
| 23 | Wed 19 Jan 2022 | 51-1 v ValenciaValencia 1-1 Sevilla | Spanish La Liga |
| 24 | Sat 22 Jan 2022 | 52-2 v Celta VigoSevilla 2-2 Celta Vigo | Spanish La Liga |
| 25 | Sat 5 Feb 2022 | 50-0 v OsasunaOsasuna 0-0 Sevilla | Spanish La Liga |
| 26 | Thu 17 Feb 2022 | 53-1 v Dinamo ZagrebSevilla 3-1 Dinamo Zagreb | UEFA Europa League Round of 32 |
| 27 | Sun 20 Feb 2022 | 5 1-1 v EspanyolEspanyol 1-1 Sevilla | Spanish La Liga |
| 28 | Thu 24 Feb 2022 | 50-1 v Dinamo ZagrebDinamo Zagreb 1-0 Sevilla | UEFA Europa League Round of 32 |
| 29 | Fri 4 Mar 2022 | 50-0 v AlavésAlavés 0-0 Sevilla | Spanish La Liga |
| 30 | Thu 10 Mar 2022 | 5 1-0 v West Ham UnitedSevilla 1-0 West Ham United | UEFA Europa League Round of 16 |
| 31 | Sun 13 Mar 2022 | 5 1-1 v Rayo VallecanoRayo Vallecano 1-1 Sevilla | Spanish La Liga |
| 32 | Sun 20 Mar 2022 | 50-0 v Real SociedadSevilla 0-0 Real Sociedad | Spanish La Liga |
| 33 | Sun 3 Apr 2022 | 5 0-1 v BarcelonaBarcelona 1-0 Sevilla | Spanish La Liga |
| 34 | Fri 8 Apr 2022 | 54-2 v GranadaSevilla 4-2 Granada | Spanish La Liga |
| 35 | Sun 17 Apr 2022 | 52-3 v Real MadridSevilla 2-3 Real Madrid | Spanish La Liga |
| 36 | Thu 21 Apr 2022 | 53-2 v LevanteLevante 2-3 Sevilla | Spanish La Liga |
| 37 | Fri 29 Apr 2022 | 51-1 v CádizSevilla 1-1 Cádiz | Spanish La Liga |
| 38 | Wed 11 May 2022 | 50-0 v MallorcaSevilla 0-0 Mallorca | Spanish La Liga |
| 39 | Sun 15 May 2022 | 51-1 v Atlético MadridAtlético Madrid 1-1 Sevilla | Spanish La Liga |
| 40 | Sun 22 May 2022 | 51-0 v Athletic BilbaoSevilla 1-0 Athletic Bilbao | Spanish La Liga |
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