| 1 | Fri 20 Aug 2021 | 111-1 v CádizReal Betis 1-1 Cádiz | Spanish La Liga |
| 2 | Sat 28 Aug 2021 | 110-1 v Real MadridReal Betis 0-1 Real Madrid | Spanish La Liga |
| 3 | Mon 13 Sep 2021 | 112-1 v GranadaGranada 1-2 Real Betis | Spanish La Liga |
| 4 | Sun 26 Sep 2021 | 112-0 v GetafeReal Betis 2-0 Getafe | Spanish La Liga |
| 5 | Thu 30 Sep 2021 | 113-1 v Ferencvárosi TCFerencvárosi TC 1-3 Real Betis | UEFA Europa League Group G |
| 6 | Sun 3 Oct 2021 | 110-2 v VillarrealVillarreal 2-0 Real Betis | Spanish La Liga |
| 7 | Mon 18 Oct 2021 | 111-0 v AlavésAlavés 0-1 Real Betis | Spanish La Liga |
| 8 | Sun 31 Oct 2021 | 110-3 v Atlético MadridAtlético Madrid 3-0 Real Betis | Spanish La Liga |
| 9 | Sun 7 Nov 2021 | 11 0-2 v SevillaReal Betis 0-2 Sevilla | Spanish La Liga |
| 10 | Sun 21 Nov 2021 | 113-0 v ElcheElche 0-3 Real Betis | Spanish La Liga |
| 11 | Thu 25 Nov 2021 | 112-0 v Ferencvárosi TCReal Betis 2-0 Ferencvárosi TC | UEFA Europa League Group G |
| 12 | Sat 4 Dec 2021 | 111-0 v BarcelonaBarcelona 0-1 Real Betis | Spanish La Liga |
| 13 | Thu 9 Dec 2021 | 112-3 v CelticCeltic 3-2 Real Betis | UEFA Europa League Group G |
| 14 | Sun 12 Dec 2021 | 114-0 v Real SociedadReal Betis 4-0 Real Sociedad | Spanish La Liga |
| 15 | Sun 2 Jan 2022 | 110-2 v Celta VigoReal Betis 0-2 Celta Vigo | Spanish La Liga |
| 16 | Sun 9 Jan 2022 | 111-1 v Rayo VallecanoRayo Vallecano 1-1 Real Betis | Spanish La Liga |
| 17 | Fri 21 Jan 2022 | 114-1 v EspanyolEspanyol 1-4 Real Betis | Spanish La Liga |
| 18 | Sun 6 Feb 2022 | 110-2 v VillarrealReal Betis 0-2 Villarreal | Spanish La Liga |
| 19 | Sun 13 Feb 2022 | 114-2 v LevanteLevante 2-4 Real Betis | Spanish La Liga |
| 20 | Thu 17 Feb 2022 | 11 3-2 v Zenit St PetersburgZenit St Petersburg 2-3 Real Betis | UEFA Europa League Round of 32 |
| 21 | Sun 20 Feb 2022 | 112-1 v MallorcaReal Betis 2-1 Mallorca | Spanish La Liga |
| 22 | Thu 24 Feb 2022 | 110-0 v Zenit St PetersburgReal Betis 0-0 Zenit St Petersburg | UEFA Europa League Round of 32 |
| 23 | Sun 27 Feb 2022 | 111-2 v SevillaSevilla 2-1 Real Betis | Spanish La Liga |
| 24 | Sun 6 Mar 2022 | 11 1-3 v Atlético MadridReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 25 | Wed 9 Mar 2022 | 111-2 v Eintracht FrankfurtReal Betis 1-2 Eintracht Frankfurt | UEFA Europa League Round of 16 |
| 26 | Sat 9 Apr 2022 | 112-1 v CádizCádiz 1-2 Real Betis | Spanish La Liga |
| 27 | Tue 19 Apr 2022 | 110-1 v ElcheReal Betis 0-1 Elche | Spanish La Liga |
| 28 | Mon 2 May 2022 | 110-0 v GetafeGetafe 0-0 Real Betis | Spanish La Liga |
| 29 | Fri 20 May 2022 | 110-0 v Real MadridReal Madrid 0-0 Real Betis | Spanish La Liga |
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