| 1 | Sat 14 Aug 2021 | 32-3 v Fatih KaragümrükFatih Karagümrük 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 2 | Sat 21 Aug 2021 | 30-0 v BeşiktaşGazişehir Gaziantep 0-0 Beşiktaş | Turkish Süper Lig |
| 3 | Sat 28 Aug 2021 | 3 0-2 v Yeni MalatyasporYeni Malatyaspor 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 4 | Mon 13 Sep 2021 | 32-0 v AntalyasporGazişehir Gaziantep 2-0 Antalyaspor | Turkish Süper Lig |
| 5 | Sat 18 Sep 2021 | 31-1 v SivassporSivasspor 1-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 6 | Wed 22 Sep 2021 | 31-0 v İstanbul BaşakşehirGazişehir Gaziantep 1-0 İstanbul Başakşehir | Turkish Süper Lig |
| 7 | Sat 25 Sep 2021 | 3 0-4 v Adana DemirsporAdana Demirspor 4-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 8 | Sat 23 Oct 2021 | 31-1 v GiresunsporGazişehir Gaziantep 1-1 Giresunspor | Turkish Süper Lig |
| 9 | Sun 31 Oct 2021 | 30-2 v GalatasarayGalatasaray 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 10 | Fri 5 Nov 2021 | 32-0 v Kasımpaşa SKGazişehir Gaziantep 2-0 Kasımpaşa SK | Turkish Süper Lig |
| 11 | Mon 22 Nov 2021 | 3 0-3 v TrabzonsporTrabzonspor 3-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 12 | Sun 28 Nov 2021 | 3 3-2 v KonyasporGazişehir Gaziantep 3-2 Konyaspor | Turkish Süper Lig |
| 13 | Mon 13 Dec 2021 | 33-2 v FenerbahçeGazişehir Gaziantep 3-2 Fenerbahçe | Turkish Süper Lig |
| 14 | Sun 19 Dec 2021 | 30-0 v KayserisporKayserispor 0-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 15 | Wed 22 Dec 2021 | 32-1 v AlanyasporGazişehir Gaziantep 2-1 Alanyaspor | Turkish Süper Lig |
| 16 | Sun 26 Dec 2021 | 31-0 v Çaykur RizesporÇaykur Rizespor 0-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 17 | Fri 14 Jan 2022 | 30-1 v BeşiktaşBeşiktaş 1-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 18 | Sun 23 Jan 2022 | 3 0-0 v AntalyasporAntalyaspor 0-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 19 | Sat 5 Feb 2022 | 35-1 v SivassporGazişehir Gaziantep 5-1 Sivasspor | Turkish Süper Lig |
| 20 | Sat 12 Feb 2022 | 30-2 v İstanbul Başakşehirİstanbul Başakşehir 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 21 | Sun 20 Feb 2022 | 3 0-3 v Adana DemirsporGazişehir Gaziantep 0-3 Adana Demirspor | Turkish Süper Lig |
| 22 | Wed 23 Feb 2022 | 30-0 v Yeni MalatyasporGazişehir Gaziantep 0-0 Yeni Malatyaspor | Turkish Süper Lig |
| 23 | Sun 27 Feb 2022 | 32-3 v AltayAltay 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 24 | Mon 7 Mar 2022 | 32-2 v HataysporGazişehir Gaziantep 2-2 Hatayspor | Turkish Süper Lig |
| 25 | Mon 14 Mar 2022 | 31-2 v GiresunsporGiresunspor 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 26 | Sun 20 Mar 2022 | 33-1 v GalatasarayGazişehir Gaziantep 3-1 Galatasaray | Turkish Süper Lig |
| 27 | Sun 3 Apr 2022 | 3 1-2 v Kasımpaşa SKKasımpaşa SK 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 28 | Sat 23 Apr 2022 | 31-1 v Göztepe SKGazişehir Gaziantep 1-1 Göztepe SK | Turkish Süper Lig |
| 29 | Fri 29 Apr 2022 | 3 2-3 v FenerbahçeFenerbahçe 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 30 | Fri 6 May 2022 | 31-1 v KayserisporGazişehir Gaziantep 1-1 Kayserispor | Turkish Süper Lig |
| 31 | Fri 20 May 2022 | 32-0 v Çaykur RizesporGazişehir Gaziantep 2-0 Çaykur Rizespor | Turkish Süper Lig |
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