| 1 | Sat 14 Aug 2021 | 27 2-3 v Fatih KaragümrükFatih Karagümrük 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 2 | Sat 21 Aug 2021 | 27 0-0 v BeşiktaşGazişehir Gaziantep 0-0 Beşiktaş | Turkish Süper Lig |
| 3 | Sat 28 Aug 2021 | 27 0-2 v Yeni MalatyasporYeni Malatyaspor 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 4 | Mon 13 Sep 2021 | 272-0 v AntalyasporGazişehir Gaziantep 2-0 Antalyaspor | Turkish Süper Lig |
| 5 | Sat 18 Sep 2021 | 271-1 v SivassporSivasspor 1-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 6 | Sun 3 Oct 2021 | 274-1 v AltayGazişehir Gaziantep 4-1 Altay | Turkish Süper Lig |
| 7 | Mon 18 Oct 2021 | 271-2 v HataysporHatayspor 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 8 | Sat 23 Oct 2021 | 27 1-1 v GiresunsporGazişehir Gaziantep 1-1 Giresunspor | Turkish Süper Lig |
| 9 | Mon 22 Nov 2021 | 270-3 v TrabzonsporTrabzonspor 3-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 10 | Sun 28 Nov 2021 | 273-2 v KonyasporGazişehir Gaziantep 3-2 Konyaspor | Turkish Süper Lig |
| 11 | Mon 6 Dec 2021 | 271-2 v Göztepe SKGöztepe SK 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 12 | Mon 13 Dec 2021 | 273-2 v FenerbahçeGazişehir Gaziantep 3-2 Fenerbahçe | Turkish Süper Lig |
| 13 | Sun 19 Dec 2021 | 27 0-0 v KayserisporKayserispor 0-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 14 | Sat 8 Jan 2022 | 273-1 v Fatih KaragümrükGazişehir Gaziantep 3-1 Fatih Karagümrük | Turkish Süper Lig |
| 15 | Sun 23 Jan 2022 | 270-0 v AntalyasporAntalyaspor 0-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 16 | Sat 5 Feb 2022 | 275-1 v SivassporGazişehir Gaziantep 5-1 Sivasspor | Turkish Süper Lig |
| 17 | Sat 12 Feb 2022 | 27 0-2 v İstanbul Başakşehirİstanbul Başakşehir 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 18 | Sun 20 Feb 2022 | 270-3 v Adana DemirsporGazişehir Gaziantep 0-3 Adana Demirspor | Turkish Süper Lig |
| 19 | Fri 29 Apr 2022 | 272-3 v FenerbahçeFenerbahçe 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 20 | Fri 6 May 2022 | 271-1 v KayserisporGazişehir Gaziantep 1-1 Kayserispor | Turkish Süper Lig |
| 21 | Sun 15 May 2022 | 270-3 v AlanyasporAlanyaspor 3-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 22 | Fri 20 May 2022 | 272-0 v Çaykur RizesporGazişehir Gaziantep 2-0 Çaykur Rizespor | Turkish Süper Lig |
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