| 1 | Sat 14 Aug 2021 | 28 2-3 v Fatih KaragümrükFatih Karagümrük 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 2 | Sat 28 Aug 2021 | 280-2 v Yeni MalatyasporYeni Malatyaspor 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 3 | Mon 13 Sep 2021 | 282-0 v AntalyasporGazişehir Gaziantep 2-0 Antalyaspor | Turkish Süper Lig |
| 4 | Sat 18 Sep 2021 | 281-1 v SivassporSivasspor 1-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 5 | Wed 22 Sep 2021 | 281-0 v İstanbul BaşakşehirGazişehir Gaziantep 1-0 İstanbul Başakşehir | Turkish Süper Lig |
| 6 | Sat 25 Sep 2021 | 280-4 v Adana DemirsporAdana Demirspor 4-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 7 | Sun 3 Oct 2021 | 28 4-1 v AltayGazişehir Gaziantep 4-1 Altay | Turkish Süper Lig |
| 8 | Mon 18 Oct 2021 | 281-2 v HataysporHatayspor 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 9 | Sat 23 Oct 2021 | 281-1 v GiresunsporGazişehir Gaziantep 1-1 Giresunspor | Turkish Süper Lig |
| 10 | Mon 22 Nov 2021 | 280-3 v TrabzonsporTrabzonspor 3-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 11 | Sun 28 Nov 2021 | 283-2 v KonyasporGazişehir Gaziantep 3-2 Konyaspor | Turkish Süper Lig |
| 12 | Mon 6 Dec 2021 | 281-2 v Göztepe SKGöztepe SK 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 13 | Mon 13 Dec 2021 | 283-2 v FenerbahçeGazişehir Gaziantep 3-2 Fenerbahçe | Turkish Süper Lig |
| 14 | Sat 8 Jan 2022 | 283-1 v Fatih KaragümrükGazişehir Gaziantep 3-1 Fatih Karagümrük | Turkish Süper Lig |
| 15 | Fri 14 Jan 2022 | 28 0-1 v BeşiktaşBeşiktaş 1-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 16 | Sat 5 Feb 2022 | 28 5-1 v SivassporGazişehir Gaziantep 5-1 Sivasspor | Turkish Süper Lig |
| 17 | Sat 12 Feb 2022 | 280-2 v İstanbul Başakşehirİstanbul Başakşehir 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 18 | Sun 20 Feb 2022 | 280-3 v Adana DemirsporGazişehir Gaziantep 0-3 Adana Demirspor | Turkish Süper Lig |
| 19 | Sun 27 Feb 2022 | 282-3 v AltayAltay 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 20 | Mon 7 Mar 2022 | 282-2 v HataysporGazişehir Gaziantep 2-2 Hatayspor | Turkish Süper Lig |
| 21 | Mon 14 Mar 2022 | 281-2 v GiresunsporGiresunspor 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 22 | Sun 20 Mar 2022 | 283-1 v GalatasarayGazişehir Gaziantep 3-1 Galatasaray | Turkish Süper Lig |
| 23 | Sun 3 Apr 2022 | 281-2 v Kasımpaşa SKKasımpaşa SK 2-1 Gazişehir Gaziantep | Turkish Süper Lig |
| 24 | Sat 9 Apr 2022 | 28 0-0 v TrabzonsporGazişehir Gaziantep 0-0 Trabzonspor | Turkish Süper Lig |
| 25 | Sat 23 Apr 2022 | 281-1 v Göztepe SKGazişehir Gaziantep 1-1 Göztepe SK | Turkish Süper Lig |
| 26 | Fri 29 Apr 2022 | 282-3 v FenerbahçeFenerbahçe 3-2 Gazişehir Gaziantep | Turkish Süper Lig |
| 27 | Fri 6 May 2022 | 281-1 v KayserisporGazişehir Gaziantep 1-1 Kayserispor | Turkish Süper Lig |
| 28 | Sun 15 May 2022 | 28 0-3 v AlanyasporAlanyaspor 3-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 29 | Fri 20 May 2022 | 282-0 v Çaykur RizesporGazişehir Gaziantep 2-0 Çaykur Rizespor | Turkish Süper Lig |
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