| 1 | Sat 7 Aug 2021 | 172-3 v Stoke CityStoke City 3-2 Reading | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 172-1 v Preston North EndReading 2-1 Preston North End | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 172-3 v Bristol CityReading 2-3 Bristol City | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 171-2 v Coventry CityCoventry City 2-1 Reading | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 17 0-4 v Huddersfield TownHuddersfield Town 4-0 Reading | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 173-3 v Queens Park RangersReading 3-3 Queens Park Rangers | Sky Bet Championship |
| 7 | Tue 14 Sep 2021 | 173-1 v Peterborough UnitedReading 3-1 Peterborough United | Sky Bet Championship |
| 8 | Sat 18 Sep 2021 | 172-1 v FulhamFulham 1-2 Reading | Sky Bet Championship |
| 9 | Sat 25 Sep 2021 | 171-0 v MiddlesbroughReading 1-0 Middlesbrough | Sky Bet Championship |
| 10 | Wed 29 Sep 2021 | 170-1 v Derby CountyDerby County 1-0 Reading | Sky Bet Championship |
| 11 | Sat 2 Oct 2021 | 171-0 v Cardiff CityCardiff City 0-1 Reading | Sky Bet Championship |
| 12 | Sat 16 Oct 2021 | 171-0 v BarnsleyReading 1-0 Barnsley | Sky Bet Championship |
| 13 | Wed 20 Oct 2021 | 172-3 v BlackpoolReading 2-3 Blackpool | Sky Bet Championship |
| 14 | Sat 23 Oct 2021 | 170-2 v Blackburn RoversBlackburn Rovers 2-0 Reading | Sky Bet Championship |
| 15 | Sat 30 Oct 2021 | 170-2 v AFC BournemouthReading 0-2 AFC Bournemouth | Sky Bet Championship |
| 16 | Sat 6 Nov 2021 | 172-1 v Birmingham CityBirmingham City 1-2 Reading | Sky Bet Championship |
| 17 | Thu 11 Nov 2021 | 21-1 v EthiopiaEthiopia 1-1 Ghana | World Cup Qualification (Africa) Group G |
| 18 | Sun 14 Nov 2021 | 2 1-0 v South AfricaGhana 1-0 South Africa | World Cup Qualification (Africa) Group G |
| 19 | Sat 20 Nov 2021 | 171-1 v Nottingham ForestReading 1-1 Nottingham Forest | Sky Bet Championship |
| 20 | Tue 23 Nov 2021 | 170-1 v Sheffield UnitedReading 0-1 Sheffield United | Sky Bet Championship |
| 21 | Sat 27 Nov 2021 | 173-2 v Swansea CitySwansea City 2-3 Reading | Sky Bet Championship |
| 22 | Sat 4 Dec 2021 | 171-1 v Hull CityReading 1-1 Hull City | Sky Bet Championship |
| 23 | Mon 10 Jan 2022 | 20-1 v MoroccoMorocco 1-0 Ghana | Africa Cup of Nations Group C |
| 24 | Fri 14 Jan 2022 | 21-1 v GabonGabon 1-1 Ghana | Africa Cup of Nations Group C |
| 25 | Sat 22 Jan 2022 | 17 3-4 v Huddersfield TownReading 3-4 Huddersfield Town | Sky Bet Championship |
| 26 | Sat 29 Jan 2022 | 170-4 v Queens Park RangersQueens Park Rangers 4-0 Reading | Sky Bet Championship |
| 27 | Wed 9 Feb 2022 | 171-2 v Bristol CityBristol City 2-1 Reading | Sky Bet Championship |
| 28 | Sat 12 Feb 2022 | 172-3 v Coventry CityReading 2-3 Coventry City | Sky Bet Championship |
| 29 | Wed 16 Feb 2022 | 17 0-0 v Peterborough UnitedPeterborough United 0-0 Reading | Sky Bet Championship |
| 30 | Sat 19 Feb 2022 | 173-2 v Preston North EndPreston North End 2-3 Reading | Sky Bet Championship |
| 31 | Tue 22 Feb 2022 | 172-1 v Birmingham CityReading 2-1 Birmingham City | Sky Bet Championship |
| 32 | Sat 26 Feb 2022 | 171-4 v BlackpoolBlackpool 4-1 Reading | Sky Bet Championship |
| 33 | Sat 5 Mar 2022 | 17 0-1 v MillwallReading 0-1 Millwall | Sky Bet Championship |
| 34 | Sat 12 Mar 2022 | 17 0-4 v Nottingham ForestNottingham Forest 4-0 Reading | Sky Bet Championship |
| 35 | Tue 15 Mar 2022 | 171-1 v AFC BournemouthAFC Bournemouth 1-1 Reading | Sky Bet Championship |
| 36 | Sat 19 Mar 2022 | 17 1-0 v Blackburn RoversReading 1-0 Blackburn Rovers | Sky Bet Championship |
| 37 | Tue 29 Mar 2022 | 21-1 v NigeriaNigeria 1-1 Ghana | World Cup Qualification (Africa) Third Round |
| 38 | Sat 2 Apr 2022 | 171-1 v BarnsleyBarnsley 1-1 Reading | Sky Bet Championship |
| 39 | Tue 5 Apr 2022 | 172-1 v Stoke CityReading 2-1 Stoke City | Sky Bet Championship |
| 40 | Sat 9 Apr 2022 | 171-2 v Cardiff CityReading 1-2 Cardiff City | Sky Bet Championship |
| 41 | Fri 15 Apr 2022 | 17 2-1 v Sheffield UnitedSheffield United 1-2 Reading | Sky Bet Championship |
| 42 | Mon 18 Apr 2022 | 174-4 v Swansea CityReading 4-4 Swansea City | Sky Bet Championship |
| 43 | Sat 23 Apr 2022 | 170-3 v Hull CityHull City 3-0 Reading | Sky Bet Championship |
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