| 1 | Thu 4 Aug 2022 | 23-1 v ČukaričkiČukarički 1-3 FC Twente | UEFA Europa Conference League Third Qualifying Round |
| 2 | Sun 7 Aug 2022 | 21-0 v NEC NijmegenNEC Nijmegen 0-1 FC Twente | Dutch Eredivisie |
| 3 | Thu 11 Aug 2022 | 24-1 v ČukaričkiFC Twente 4-1 Čukarički | UEFA Europa Conference League Third Qualifying Round |
| 4 | Thu 18 Aug 2022 | 21-2 v FiorentinaFiorentina 2-1 FC Twente | UEFA Europa Conference League Play-off |
| 5 | Thu 25 Aug 2022 | 2 0-0 v FiorentinaFC Twente 0-0 Fiorentina | UEFA Europa Conference League Play-off |
| 6 | Sun 28 Aug 2022 | 20-1 v VolendamVolendam 1-0 FC Twente | Dutch Eredivisie |
| 7 | Wed 31 Aug 2022 | 24-0 v Excelsior RotterdamFC Twente 4-0 Excelsior Rotterdam | Dutch Eredivisie |
| 8 | Sat 3 Sep 2022 | 22-1 v PSV EindhovenFC Twente 2-1 PSV Eindhoven | Dutch Eredivisie |
| 9 | Sun 11 Sep 2022 | 2 1-1 v AZ AlkmaarAZ Alkmaar 1-1 FC Twente | Dutch Eredivisie |
| 10 | Sun 18 Sep 2022 | 21-2 v sc Heerenveensc Heerenveen 2-1 FC Twente | Dutch Eredivisie |
| 11 | Sat 1 Oct 2022 | 23-0 v VitesseFC Twente 3-0 Vitesse | Dutch Eredivisie |
| 12 | Sun 9 Oct 2022 | 20-2 v FeyenoordFeyenoord 2-0 FC Twente | Dutch Eredivisie |
| 13 | Sun 16 Oct 2022 | 23-0 v FC GroningenFC Twente 3-0 FC Groningen | Dutch Eredivisie |
| 14 | Sun 23 Oct 2022 | 21-0 v SC CambuurSC Cambuur 0-1 FC Twente | Dutch Eredivisie |
| 15 | Sun 30 Oct 2022 | 23-0 v RKC WaalwijkFC Twente 3-0 RKC Waalwijk | Dutch Eredivisie |
| 16 | Sun 6 Nov 2022 | 2 1-1 v Go Ahead EaglesFC Twente 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 17 | Fri 11 Nov 2022 | 21-1 v Sparta RotterdamSparta Rotterdam 1-1 FC Twente | Dutch Eredivisie |
| 18 | Fri 6 Jan 2023 | 2 2-0 v FC EmmenFC Twente 2-0 FC Emmen | Dutch Eredivisie |
| 19 | Sat 14 Jan 2023 | 20-0 v AjaxAjax 0-0 FC Twente | Dutch Eredivisie |
| 20 | Sun 22 Jan 2023 | 22-0 v FC UtrechtFC Twente 2-0 FC Utrecht | Dutch Eredivisie |
| 21 | Wed 25 Jan 2023 | 22-2 v VitesseVitesse 2-2 FC Twente | Dutch Eredivisie |
| 22 | Sun 29 Jan 2023 | 21-1 v FeyenoordFC Twente 1-1 Feyenoord | Dutch Eredivisie |
| 23 | Sun 5 Feb 2023 | 21-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 24 | Sun 12 Feb 2023 | 23-0 v VolendamFC Twente 3-0 Volendam | Dutch Eredivisie |
| 25 | Sun 19 Feb 2023 | 20-2 v Go Ahead EaglesGo Ahead Eagles 2-0 FC Twente | Dutch Eredivisie |
| 26 | Sun 26 Feb 2023 | 21-3 v PSV EindhovenPSV Eindhoven 3-1 FC Twente | Dutch Eredivisie |
| 27 | Sat 4 Mar 2023 | 23-3 v sc HeerenveenFC Twente 3-3 sc Heerenveen | Dutch Eredivisie |
| 28 | Sat 11 Mar 2023 | 2 3-0 v Fortuna SittardFortuna Sittard 0-3 FC Twente | Dutch Eredivisie |
| 29 | Sun 19 Mar 2023 | 22-1 v AZ AlkmaarFC Twente 2-1 AZ Alkmaar | Dutch Eredivisie |
| 30 | Sun 7 May 2023 | 23-0 v FC EmmenFC Emmen 0-3 FC Twente | Dutch Eredivisie |
| 31 | Sun 21 May 2023 | 25-0 v RKC WaalwijkRKC Waalwijk 0-5 FC Twente | Dutch Eredivisie |
| 32 | Sun 28 May 2023 | 23-1 v AjaxFC Twente 3-1 Ajax | Dutch Eredivisie |
| 33 | Sun 4 Jun 2023 | 24-0 v sc HeerenveenFC Twente 4-0 sc Heerenveen | Dutch Eredivisie Play-off |
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