| 1 | Sat 27 Aug 2022 | 243-0 v Mainz 05Mainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 3 Sep 2022 | 242-3 v SC FreiburgBayer 04 Leverkusen 2-3 SC Freiburg | German Bundesliga |
| 3 | Tue 4 Oct 2022 | 240-2 v FC PortoFC Porto 2-0 Bayer 04 Leverkusen | UEFA Champions League Group B |
| 4 | Wed 12 Oct 2022 | 240-3 v FC PortoBayer 04 Leverkusen 0-3 FC Porto | UEFA Champions League Group B |
| 5 | Sat 22 Oct 2022 | 24 2-2 v VfL WolfsburgBayer 04 Leverkusen 2-2 VfL Wolfsburg | German Bundesliga |
| 6 | Wed 26 Oct 2022 | 242-2 v Atlético MadridAtlético Madrid 2-2 Bayer 04 Leverkusen | UEFA Champions League Group B |
| 7 | Sat 29 Oct 2022 | 240-2 v RB LeipzigRB Leipzig 2-0 Bayer 04 Leverkusen | German Bundesliga |
| 8 | Sun 6 Nov 2022 | 245-0 v 1 FC Union BerlinBayer 04 Leverkusen 5-0 1 FC Union Berlin | German Bundesliga |
| 9 | Wed 9 Nov 2022 | 242-1 v 1 FC Köln1 FC Köln 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 10 | Sat 12 Nov 2022 | 242-0 v VfB StuttgartBayer 04 Leverkusen 2-0 VfB Stuttgart | German Bundesliga |
| 11 | Sun 5 Mar 2023 | 244-1 v Hertha BerlinBayer 04 Leverkusen 4-1 Hertha Berlin | German Bundesliga |
| 12 | Thu 16 Mar 2023 | 242-0 v Ferencvárosi TCFerencvárosi TC 0-2 Bayer 04 Leverkusen | UEFA Europa League Round of 16 |
| 13 | Sun 19 Mar 2023 | 242-1 v Bayern MunichBayer 04 Leverkusen 2-1 Bayern Munich | German Bundesliga |
| 14 | Sat 8 Apr 2023 | 243-1 v Eintracht FrankfurtBayer 04 Leverkusen 3-1 Eintracht Frankfurt | German Bundesliga |
| 15 | Sun 23 Apr 2023 | 242-0 v RB LeipzigBayer 04 Leverkusen 2-0 RB Leipzig | German Bundesliga |
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