| 1 | Sat 6 Aug 2022 | 37 2-1 v VfL BochumVfL Bochum 1-2 Mainz 05 | German Bundesliga |
| 2 | Sun 14 Aug 2022 | 370-0 v 1 FC Union BerlinMainz 05 0-0 1 FC Union Berlin | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 372-1 v FC AugsburgFC Augsburg 1-2 Mainz 05 | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 37 0-3 v Bayer 04 LeverkusenMainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Sun 4 Sep 2022 | 371-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 Mainz 05 | German Bundesliga |
| 6 | Sat 10 Sep 2022 | 371-4 v 1899 Hoffenheim1899 Hoffenheim 4-1 Mainz 05 | German Bundesliga |
| 7 | Sat 1 Oct 2022 | 371-2 v SC FreiburgSC Freiburg 2-1 Mainz 05 | German Bundesliga |
| 8 | Sat 8 Oct 2022 | 371-1 v RB LeipzigMainz 05 1-1 RB Leipzig | German Bundesliga |
| 9 | Sat 29 Oct 2022 | 372-6 v Bayern MunichBayern Munich 6-2 Mainz 05 | German Bundesliga |
| 10 | Sat 5 Nov 2022 | 370-3 v VfL WolfsburgMainz 05 0-3 VfL Wolfsburg | German Bundesliga |
| 11 | Sat 1 Apr 2023 | 373-0 v RB LeipzigRB Leipzig 0-3 Mainz 05 | German Bundesliga |
| 12 | Fri 5 May 2023 | 372-3 v FC Schalke 04Mainz 05 2-3 FC Schalke 04 | German Bundesliga |
| 13 | Sat 13 May 2023 | 370-3 v Eintracht FrankfurtEintracht Frankfurt 3-0 Mainz 05 | German Bundesliga |
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