| 1 | Sat 6 Aug 2022 | 31-3 v Borussia MönchengladbachBorussia Mönchengladbach 3-1 1899 Hoffenheim | German Bundesliga |
| 2 | Sat 13 Aug 2022 | 33-2 v VfL Bochum1899 Hoffenheim 3-2 VfL Bochum | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 33-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-3 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 31-0 v FC Augsburg1899 Hoffenheim 1-0 FC Augsburg | German Bundesliga |
| 5 | Fri 2 Sep 2022 | 30-1 v Borussia DortmundBorussia Dortmund 1-0 1899 Hoffenheim | German Bundesliga |
| 6 | Sat 10 Sep 2022 | 34-1 v Mainz 051899 Hoffenheim 4-1 Mainz 05 | German Bundesliga |
| 7 | Sun 18 Sep 2022 | 30-0 v SC Freiburg1899 Hoffenheim 0-0 SC Freiburg | German Bundesliga |
| 8 | Sun 2 Oct 2022 | 31-1 v Hertha BerlinHertha Berlin 1-1 1899 Hoffenheim | German Bundesliga |
| 9 | Fri 7 Oct 2022 | 31-2 v Werder Bremen1899 Hoffenheim 1-2 Werder Bremen | German Bundesliga |
| 10 | Sat 22 Oct 2022 | 30-2 v Bayern Munich1899 Hoffenheim 0-2 Bayern Munich | German Bundesliga |
| 11 | Sat 5 Nov 2022 | 31-3 v RB Leipzig1899 Hoffenheim 1-3 RB Leipzig | German Bundesliga |
| 12 | Wed 9 Nov 2022 | 32-4 v Eintracht FrankfurtEintracht Frankfurt 4-2 1899 Hoffenheim | German Bundesliga |
| 13 | Sat 12 Nov 2022 | 31-2 v VfL Wolfsburg1899 Hoffenheim 1-2 VfL Wolfsburg | German Bundesliga |
| 14 | Sat 21 Jan 2023 | 31-3 v 1 FC Union Berlin1 FC Union Berlin 3-1 1899 Hoffenheim | German Bundesliga |
| 15 | Tue 24 Jan 2023 | 32-2 v VfB Stuttgart1899 Hoffenheim 2-2 VfB Stuttgart | German Bundesliga |
| 16 | Sat 28 Jan 2023 | 31-4 v Borussia Mönchengladbach1899 Hoffenheim 1-4 Borussia Mönchengladbach | German Bundesliga |
| 17 | Fri 17 Feb 2023 | 3 0-1 v FC AugsburgFC Augsburg 1-0 1899 Hoffenheim | German Bundesliga |
| 18 | Sat 25 Feb 2023 | 30-1 v Borussia Dortmund1899 Hoffenheim 0-1 Borussia Dortmund | German Bundesliga |
| 19 | Sat 4 Mar 2023 | 30-1 v Mainz 05Mainz 05 1-0 1899 Hoffenheim | German Bundesliga |
| 20 | Sun 12 Mar 2023 | 31-2 v SC FreiburgSC Freiburg 2-1 1899 Hoffenheim | German Bundesliga |
| 21 | Sat 18 Mar 2023 | 33-1 v Hertha Berlin1899 Hoffenheim 3-1 Hertha Berlin | German Bundesliga |
| 22 | Sun 2 Apr 2023 | 32-1 v Werder BremenWerder Bremen 1-2 1899 Hoffenheim | German Bundesliga |
| 23 | Sun 9 Apr 2023 | 32-0 v FC Schalke 041899 Hoffenheim 2-0 FC Schalke 04 | German Bundesliga |
| 24 | Sat 15 Apr 2023 | 31-1 v Bayern MunichBayern Munich 1-1 1899 Hoffenheim | German Bundesliga |
| 25 | Sat 22 Apr 2023 | 31-3 v 1 FC Köln1899 Hoffenheim 1-3 1 FC Köln | German Bundesliga |
| 26 | Sat 29 Apr 2023 | 30-1 v RB LeipzigRB Leipzig 1-0 1899 Hoffenheim | German Bundesliga |
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