| 1 | Sat 6 Aug 2022 | 32-1 v VfL BochumVfL Bochum 1-2 Mainz 05 | German Bundesliga |
| 2 | Sun 14 Aug 2022 | 30-0 v 1 FC Union BerlinMainz 05 0-0 1 FC Union Berlin | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 32-1 v FC AugsburgFC Augsburg 1-2 Mainz 05 | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 30-3 v Bayer 04 LeverkusenMainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Sun 4 Sep 2022 | 31-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 Mainz 05 | German Bundesliga |
| 6 | Sat 10 Sep 2022 | 31-4 v 1899 Hoffenheim1899 Hoffenheim 4-1 Mainz 05 | German Bundesliga |
| 7 | Fri 16 Sep 2022 | 31-1 v Hertha BerlinMainz 05 1-1 Hertha Berlin | German Bundesliga |
| 8 | Sat 1 Oct 2022 | 31-2 v SC FreiburgSC Freiburg 2-1 Mainz 05 | German Bundesliga |
| 9 | Sat 8 Oct 2022 | 31-1 v RB LeipzigMainz 05 1-1 RB Leipzig | German Bundesliga |
| 10 | Sat 15 Oct 2022 | 32-0 v Werder BremenWerder Bremen 0-2 Mainz 05 | German Bundesliga |
| 11 | Fri 21 Oct 2022 | 35-0 v 1 FC KölnMainz 05 5-0 1 FC Köln | German Bundesliga |
| 12 | Sat 29 Oct 2022 | 32-6 v Bayern MunichBayern Munich 6-2 Mainz 05 | German Bundesliga |
| 13 | Sat 5 Nov 2022 | 30-3 v VfL WolfsburgMainz 05 0-3 VfL Wolfsburg | German Bundesliga |
| 14 | Wed 9 Nov 2022 | 30-1 v FC Schalke 04FC Schalke 04 1-0 Mainz 05 | German Bundesliga |
| 15 | Sun 13 Nov 2022 | 3 1-1 v Eintracht FrankfurtMainz 05 1-1 Eintracht Frankfurt | German Bundesliga |
| 16 | Sat 21 Jan 2023 | 31-1 v VfB StuttgartVfB Stuttgart 1-1 Mainz 05 | German Bundesliga |
| 17 | Wed 25 Jan 2023 | 31-2 v Borussia DortmundMainz 05 1-2 Borussia Dortmund | German Bundesliga |
| 18 | Sun 19 Feb 2023 | 33-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-3 Mainz 05 | German Bundesliga |
| 19 | Fri 24 Feb 2023 | 34-0 v Borussia MönchengladbachMainz 05 4-0 Borussia Mönchengladbach | German Bundesliga |
| 20 | Sat 11 Mar 2023 | 31-1 v Hertha BerlinHertha Berlin 1-1 Mainz 05 | German Bundesliga |
| 21 | Sat 1 Apr 2023 | 33-0 v RB LeipzigRB Leipzig 0-3 Mainz 05 | German Bundesliga |
| 22 | Sat 15 Apr 2023 | 31-1 v 1 FC Köln1 FC Köln 1-1 Mainz 05 | German Bundesliga |
| 23 | Sat 22 Apr 2023 | 3 3-1 v Bayern MunichMainz 05 3-1 Bayern Munich | German Bundesliga |
| 24 | Sun 30 Apr 2023 | 3 0-3 v VfL WolfsburgVfL Wolfsburg 3-0 Mainz 05 | German Bundesliga |
| 25 | Fri 5 May 2023 | 32-3 v FC Schalke 04Mainz 05 2-3 FC Schalke 04 | German Bundesliga |
| 26 | Sat 13 May 2023 | 30-3 v Eintracht FrankfurtEintracht Frankfurt 3-0 Mainz 05 | German Bundesliga |
| 27 | Sun 21 May 2023 | 31-4 v VfB StuttgartMainz 05 1-4 VfB Stuttgart | German Bundesliga |
| 28 | Sat 27 May 2023 | 32-2 v Borussia DortmundBorussia Dortmund 2-2 Mainz 05 | German Bundesliga |
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