| 1 | Sat 13 Aug 2022 | 80-2 v AtalantaSampdoria 0-2 Atalanta | Italian Serie A |
| 2 | Mon 22 Aug 2022 | 80-0 v JuventusSampdoria 0-0 Juventus | Italian Serie A |
| 3 | Sun 28 Aug 2022 | 8 0-4 v SalernitanaSalernitana 4-0 Sampdoria | Italian Serie A |
| 4 | Wed 31 Aug 2022 | 81-1 v LazioSampdoria 1-1 Lazio | Italian Serie A |
| 5 | Sun 4 Sep 2022 | 81-2 v Hellas VeronaHellas Verona 2-1 Sampdoria | Italian Serie A |
| 6 | Sat 10 Sep 2022 | 81-2 v AC MilanSampdoria 1-2 AC Milan | Italian Serie A |
| 7 | Sat 17 Sep 2022 | 81-2 v SpeziaSpezia 2-1 Sampdoria | Italian Serie A |
| 8 | Tue 27 Sep 2022 | 84-0 v United Arab EmiratesUnited Arab Emirates 0-4 Venezuela | International Friendly |
| 9 | Sun 2 Oct 2022 | 80-3 v MonzaSampdoria 0-3 Monza | Italian Serie A |
| 10 | Sat 8 Oct 2022 | 81-1 v BolognaBologna 1-1 Sampdoria | Italian Serie A |
| 11 | Mon 17 Oct 2022 | 8 0-1 v RomaSampdoria 0-1 Roma | Italian Serie A |
| 12 | Mon 24 Oct 2022 | 81-0 v CremoneseCremonese 0-1 Sampdoria | Italian Serie A |
| 13 | Sat 29 Oct 2022 | 80-3 v Inter MilanInter Milan 3-0 Sampdoria | Italian Serie A |
| 14 | Wed 9 Nov 2022 | 80-2 v TorinoTorino 2-0 Sampdoria | Italian Serie A |
| 15 | Sat 12 Nov 2022 | 80-2 v LecceSampdoria 0-2 Lecce | Italian Serie A |
| 16 | Tue 15 Nov 2022 | 82-2 v PanamaVenezuela 2-2 Panama | International Friendly |
| 17 | Sun 20 Nov 2022 | 82-1 v SyriaVenezuela 2-1 Syria | International Friendly |
| 18 | Wed 4 Jan 2023 | 82-1 v SassuoloSassuolo 1-2 Sampdoria | Italian Serie A |
| 19 | Sun 8 Jan 2023 | 8 0-2 v NapoliSampdoria 0-2 Napoli | Italian Serie A |
| 20 | Sat 28 Jan 2023 | 80-2 v AtalantaAtalanta 2-0 Sampdoria | Italian Serie A |
| 21 | Mon 6 Feb 2023 | 8 2-2 v MonzaMonza 2-2 Sampdoria | Italian Serie A |
| 22 | Mon 13 Feb 2023 | 80-0 v Inter MilanSampdoria 0-0 Inter Milan | Italian Serie A |
| 23 | Sat 18 Feb 2023 | 8 1-2 v BolognaSampdoria 1-2 Bologna | Italian Serie A |
| 24 | Mon 27 Feb 2023 | 80-1 v LazioLazio 1-0 Sampdoria | Italian Serie A |
| 25 | Sun 5 Mar 2023 | 80-0 v SalernitanaSampdoria 0-0 Salernitana | Italian Serie A |
| 26 | Sun 12 Mar 2023 | 8 2-4 v JuventusJuventus 4-2 Sampdoria | Italian Serie A |
| 27 | Fri 24 Mar 2023 | 82-1 v Saudi ArabiaSaudi Arabia 1-2 Venezuela | International Friendly |
| 28 | Tue 28 Mar 2023 | 81-1 v UzbekistanUzbekistan 1-1 Venezuela | International Friendly |
| 29 | Sun 2 Apr 2023 | 80-3 v RomaRoma 3-0 Sampdoria | Italian Serie A |
| 30 | Sat 8 Apr 2023 | 82-3 v CremoneseSampdoria 2-3 Cremonese | Italian Serie A |
| 31 | Sun 16 Apr 2023 | 8 1-1 v LecceLecce 1-1 Sampdoria | Italian Serie A |
| 32 | Sat 22 Apr 2023 | 81-1 v SpeziaSampdoria 1-1 Spezia | Italian Serie A |
| 33 | Sun 30 Apr 2023 | 80-5 v FiorentinaFiorentina 5-0 Sampdoria | Italian Serie A |
| 34 | Wed 3 May 2023 | 8 0-2 v TorinoSampdoria 0-2 Torino | Italian Serie A |
| 35 | Mon 8 May 2023 | 80-2 v UdineseUdinese 2-0 Sampdoria | Italian Serie A |
| 36 | Mon 15 May 2023 | 81-1 v EmpoliSampdoria 1-1 Empoli | Italian Serie A |
| 37 | Sat 20 May 2023 | 81-5 v AC MilanAC Milan 5-1 Sampdoria | Italian Serie A |
| 38 | Fri 26 May 2023 | 82-2 v SassuoloSampdoria 2-2 Sassuolo | Italian Serie A |
| 39 | Sun 4 Jun 2023 | 80-2 v NapoliNapoli 2-0 Sampdoria | Italian Serie A |
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