| 1 | Sat 13 Aug 2022 | 201-2 v Shrewsbury TownWycombe Wanderers 1-2 Shrewsbury Town | Sky Bet League One |
| 2 | Tue 16 Aug 2022 | 201-3 v Exeter CityExeter City 3-1 Wycombe Wanderers | Sky Bet League One |
| 3 | Sat 20 Aug 2022 | 20 3-0 v BarnsleyBarnsley 0-3 Wycombe Wanderers | Sky Bet League One |
| 4 | Sat 27 Aug 2022 | 20 1-1 v Charlton AthleticWycombe Wanderers 1-1 Charlton Athletic | Sky Bet League One |
| 5 | Sat 3 Sep 2022 | 201-1 v Fleetwood TownFleetwood Town 1-1 Wycombe Wanderers | Sky Bet League One |
| 6 | Tue 13 Sep 2022 | 201-0 v Accrington StanleyWycombe Wanderers 1-0 Accrington Stanley | Sky Bet League One |
| 7 | Sat 17 Sep 2022 | 201-2 v Derby CountyDerby County 2-1 Wycombe Wanderers | Sky Bet League One |
| 8 | Sat 24 Sep 2022 | 20 1-3 v Sheffield WednesdaySheffield Wednesday 3-1 Wycombe Wanderers | Sky Bet League One |
| 9 | Sat 1 Oct 2022 | 200-1 v Plymouth ArgyleWycombe Wanderers 0-1 Plymouth Argyle | Sky Bet League One |
| 10 | Sat 8 Oct 2022 | 201-0 v Oxford UnitedOxford United 0-1 Wycombe Wanderers | Sky Bet League One |
| 11 | Sat 15 Oct 2022 | 203-1 v Peterborough UnitedWycombe Wanderers 3-1 Peterborough United | Sky Bet League One |
| 12 | Sat 22 Oct 2022 | 201-0 v Milton Keynes DonsMilton Keynes Dons 0-1 Wycombe Wanderers | Sky Bet League One |
| 13 | Tue 25 Oct 2022 | 202-3 v Cambridge UnitedWycombe Wanderers 2-3 Cambridge United | Sky Bet League One |
| 14 | Sat 29 Oct 2022 | 20 1-1 v MorecambeWycombe Wanderers 1-1 Morecambe | Sky Bet League One |
| 15 | Tue 1 Nov 2022 | 202-2 v Port ValeWycombe Wanderers 2-2 Port Vale | Sky Bet League One |
| 16 | Sat 5 Nov 2022 | 200-2 v WalsallWycombe Wanderers 0-2 Walsall | Emirates FA Cup First Round |
| 17 | Sat 12 Nov 2022 | 20 2-0 v Forest Green RoversForest Green Rovers 0-2 Wycombe Wanderers | Sky Bet League One |
| 18 | Sat 19 Nov 2022 | 200-1 v Cheltenham TownCheltenham Town 1-0 Wycombe Wanderers | Sky Bet League One |
| 19 | Sun 4 Dec 2022 | 20 2-0 v PortsmouthWycombe Wanderers 2-0 Portsmouth | Sky Bet League One |
| 20 | Sat 10 Dec 2022 | 200-0 v Lincoln CityLincoln City 0-0 Wycombe Wanderers | Sky Bet League One |
| 21 | Sat 17 Dec 2022 | 20 1-0 v Ipswich TownWycombe Wanderers 1-0 Ipswich Town | Sky Bet League One |
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