| 1 | Sat 6 Aug 2022 | 41-2 v Fleetwood TownFleetwood Town 2-1 Plymouth Argyle | Sky Bet League One |
| 2 | Wed 10 Aug 2022 | 40-2 v Peterborough UnitedPlymouth Argyle 0-2 Peterborough United | Carabao Cup First Round |
| 3 | Sat 13 Aug 2022 | 42-0 v Peterborough UnitedPlymouth Argyle 2-0 Peterborough United | Sky Bet League One |
| 4 | Tue 16 Aug 2022 | 41-5 v Charlton AthleticCharlton Athletic 5-1 Plymouth Argyle | Sky Bet League One |
| 5 | Sat 20 Aug 2022 | 43-0 v Forest Green RoversForest Green Rovers 0-3 Plymouth Argyle | Sky Bet League One |
| 6 | Sat 27 Aug 2022 | 42-0 v Bolton WanderersPlymouth Argyle 2-0 Bolton Wanderers | Sky Bet League One |
| 7 | Tue 30 Aug 2022 | 41-1 v Bristol RoversPlymouth Argyle 1-1 Bristol Rovers | Papa John’s Trophy |
| 8 | Sat 3 Sep 2022 | 43-2 v Derby CountyDerby County 2-3 Plymouth Argyle | Sky Bet League One |
| 9 | Tue 13 Sep 2022 | 41-0 v Oxford UnitedPlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 10 | Sat 17 Sep 2022 | 42-2 v PortsmouthPortsmouth 2-2 Plymouth Argyle | Sky Bet League One |
| 11 | Tue 20 Sep 2022 | 43-1 v Swindon TownSwindon Town 1-3 Plymouth Argyle | Papa John’s Trophy |
| 12 | Sun 25 Sep 2022 | 42-1 v Ipswich TownPlymouth Argyle 2-1 Ipswich Town | Sky Bet League One |
| 13 | Sat 1 Oct 2022 | 41-0 v Wycombe WanderersWycombe Wanderers 0-1 Plymouth Argyle | Sky Bet League One |
| 14 | Tue 4 Oct 2022 | 42-1 v Sheffield WednesdayPlymouth Argyle 2-1 Sheffield Wednesday | Sky Bet League One |
| 15 | Sat 8 Oct 2022 | 43-0 v Accrington StanleyPlymouth Argyle 3-0 Accrington Stanley | Sky Bet League One |
| 16 | Sat 15 Oct 2022 | 44-1 v Milton Keynes DonsMilton Keynes Dons 1-4 Plymouth Argyle | Sky Bet League One |
| 17 | Sat 22 Oct 2022 | 4 2-2 v Bristol RoversBristol Rovers 2-2 Plymouth Argyle | Sky Bet League One |
| 18 | Tue 25 Oct 2022 | 42-1 v Shrewsbury TownPlymouth Argyle 2-1 Shrewsbury Town | Sky Bet League One |
| 19 | Mon 31 Oct 2022 | 44-2 v Exeter CityPlymouth Argyle 4-2 Exeter City | Sky Bet League One |
| 20 | Sat 12 Nov 2022 | 4 1-1 v Lincoln CityLincoln City 1-1 Plymouth Argyle | Sky Bet League One |
| 21 | Sat 19 Nov 2022 | 42-2 v Burton AlbionBurton Albion 2-2 Plymouth Argyle | Sky Bet League One |
| 22 | Fri 2 Dec 2022 | 40-2 v Port ValePlymouth Argyle 0-2 Port Vale | Sky Bet League One |
| 23 | Sat 10 Dec 2022 | 4 0-0 v Cambridge UnitedCambridge United 0-0 Plymouth Argyle | Sky Bet League One |
| 24 | Sat 17 Dec 2022 | 42-1 v MorecambePlymouth Argyle 2-1 Morecambe | Sky Bet League One |
| 25 | Wed 21 Dec 2022 | 43-3 v AFC WimbledonPlymouth Argyle 3-3 AFC Wimbledon | Papa John’s Trophy Third Round |
| 26 | Mon 26 Dec 2022 | 41-0 v Cheltenham TownCheltenham Town 0-1 Plymouth Argyle | Sky Bet League One |
| 27 | Thu 29 Dec 2022 | 41-0 v Wycombe WanderersPlymouth Argyle 1-0 Wycombe Wanderers | Sky Bet League One |
| 28 | Sun 1 Jan 2023 | 43-1 v Milton Keynes DonsPlymouth Argyle 3-1 Milton Keynes Dons | Sky Bet League One |
| 29 | Sat 7 Jan 2023 | 40-0 v Bolton WanderersBolton Wanderers 0-0 Plymouth Argyle | Sky Bet League One |
| 30 | Sat 14 Jan 2023 | 41-1 v Ipswich TownIpswich Town 1-1 Plymouth Argyle | Sky Bet League One |
| 31 | Sat 21 Jan 2023 | 44-2 v Cheltenham TownPlymouth Argyle 4-2 Cheltenham Town | Sky Bet League One |
| 32 | Sat 4 Feb 2023 | 40-1 v Sheffield WednesdaySheffield Wednesday 1-0 Plymouth Argyle | Sky Bet League One |
| 33 | Tue 14 Feb 2023 | 43-1 v Oxford UnitedOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 34 | Sat 18 Feb 2023 | 40-0 v Fleetwood TownPlymouth Argyle 0-0 Fleetwood Town | Sky Bet League One |
| 35 | Tue 21 Feb 2023 | 41-1 v Cheltenham TownPlymouth Argyle 1-1 Cheltenham Town | Papa John’s Trophy Northern Group E |
| 36 | Sat 25 Feb 2023 | 42-5 v Peterborough UnitedPeterborough United 5-2 Plymouth Argyle | Sky Bet League One |
| 37 | Sat 4 Mar 2023 | 42-0 v Charlton AthleticPlymouth Argyle 2-0 Charlton Athletic | Sky Bet League One |
| 38 | Tue 7 Mar 2023 | 42-1 v Derby CountyPlymouth Argyle 2-1 Derby County | Sky Bet League One |
| 39 | Sat 11 Mar 2023 | 40-3 v BarnsleyBarnsley 3-0 Plymouth Argyle | Sky Bet League One |
| 40 | Sat 18 Mar 2023 | 42-0 v Forest Green RoversPlymouth Argyle 2-0 Forest Green Rovers | Sky Bet League One |
| 41 | Tue 21 Mar 2023 | 42-0 v Accrington StanleyAccrington Stanley 0-2 Plymouth Argyle | Sky Bet League One |
| 42 | Sun 2 Apr 2023 | 40-4 v Bolton WanderersBolton Wanderers 4-0 Plymouth Argyle | Papa John’s Trophy Final |
| 43 | Fri 7 Apr 2023 | 43-1 v MorecambeMorecambe 1-3 Plymouth Argyle | Sky Bet League One |
| 44 | Mon 10 Apr 2023 | 40-2 v Lincoln CityPlymouth Argyle 0-2 Lincoln City | Sky Bet League One |
| 45 | Sat 15 Apr 2023 | 41-0 v Exeter CityExeter City 0-1 Plymouth Argyle | Sky Bet League One |
| 46 | Tue 18 Apr 2023 | 42-1 v Shrewsbury TownShrewsbury Town 1-2 Plymouth Argyle | Sky Bet League One |
| 47 | Sat 22 Apr 2023 | 43-1 v Cambridge UnitedPlymouth Argyle 3-1 Cambridge United | Sky Bet League One |
| 48 | Tue 25 Apr 2023 | 42-0 v Bristol RoversPlymouth Argyle 2-0 Bristol Rovers | Sky Bet League One |
| 49 | Sat 29 Apr 2023 | 41-0 v Burton AlbionPlymouth Argyle 1-0 Burton Albion | Sky Bet League One |
| 50 | Sun 7 May 2023 | 43-1 v Port ValePort Vale 1-3 Plymouth Argyle | Sky Bet League One |
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